Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 31-49) antibody

Details for Product No. ABIN569539
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Antigen
Epitope
AA 31-49
(20), (3), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(59), (25), (23), (11), (11)
Host
Rabbit
(52), (5), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(49), (25), (9), (7), (4), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN569539
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Immunogen Synthetic peptide corresponding to amino acids 31-49 of human UBE2V1a
Specificity This antibody detects UBE2V1 / CROC1. A protein band of approximate mloecular weght of 20 kD can be seen in Jurkat, RAW and HeLa cell lysates. This antibody may also recognize isoform b of UBE2V1. Species Reactivity: Tested: Mouse, Human, Rat
Purification Protein G chromatography
Alternative Name UBE2V1 / CROC1
Background The E2 enzyme, Ubc13, and the E2 enzyme variants, Uevs, form stable, high affinity complexes for the assembly of Lys63-linked ubiquitin chains. This complex has been shown to activate NF-kB signaling pathway by linking TRAF6 to IKKs. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results suggest a new regulatory function for ubiquitin, in which IKK is activated through the assembly of Lys63-linked polyubiquitin chains. The UEV proteins are also involved in the control of differentiation.
Alternate names: CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A, UBE2V, UEV-1, UEV1, Ubiquitin-conjugating enzyme E2 variant 1
Gene ID 387522
NCBI Accession NP_001027459
UniProt Q13404
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Deng, Wang, Spencer et al.: "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain." in: Cell, Vol. 103, Issue 2, pp. 351-61, 2000 (PubMed).

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