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Details for Product No. ABIN569539

Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 31-49) antibody

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Antigen
Synonyms CIR1, UEV1, CROC1, UBE2V, UEV-1, UEV1A, CROC-1, 0610011J09Rik, AI256840, D7Bwg1382e, CROC-1B, TMEM189-UBE2V1, UBE2V1, UBE2V2
Epitope
»Alternatives AA 31-49
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN569539
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
Shipping to
Availability Discontinued
Immunogen Synthetic peptide corresponding to amino acids 31-49 of human UBE2V1a
Specificity This antibody detects UBE2V1 / CROC1. A protein band of approximate mloecular weght of 20 kD can be seen in Jurkat, RAW and HeLa cell lysates. This antibody may also recognize isoform b of UBE2V1. Species Reactivity: Tested: Mouse, Human, Rat
Purification Protein G chromatography
Alternative Name UBE2V1 / CROC1
Background The E2 enzyme, Ubc13, and the E2 enzyme variants, Uevs, form stable, high affinity complexes for the assembly of Lys63-linked ubiquitin chains. This complex has been shown to activate NF-kB signaling pathway by linking TRAF6 to IKKs. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results suggest a new regulatory function for ubiquitin, in which IKK is activated through the assembly of Lys63-linked polyubiquitin chains. The UEV proteins are also involved in the control of differentiation.
Alternate names: CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A, UBE2V, UEV-1, UEV1, Ubiquitin-conjugating enzyme E2 variant 1
Gene ID 387522
NCBI Accession NP_001027459.1
UniProt Q13404
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Deng, Wang, Spencer et al.: "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain." in: Cell, Vol. 103, Issue 2, pp. 351-61, 2000 (PubMed).

Alternatives for antigen "Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1)", type "Antibodies"
Hosts (50), (5), (4)
Reactivities (58), (25), (23), (11), (11)
Applications (46), (21), (9), (8), (4), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (3), (3), (2), (2), (2), (1), (1), (1), (1)
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