P5CS antibody (C-Term)

Catalog No. ABIN569586

Product Details anti-P5CS Antibody

Target: P5CS (ALDH18A1) (Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This P5CS antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-SEHGSLKYLH

Specificity: This antibody is expected to recognize both reported isoforms of ALDH18A1 (NP_002851.2, NP_001017423.1).

Cross-Reactivity (Details): Species reactivity (expected):Rat, Canine (Dog), Cow, Pig.
Species reactivity (tested):Human, Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_002851.2, NP_001017423.1. Genename: ALDH18A1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for P5CS

Target: P5CS (ALDH18A1) (Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))

Alternative Name: ALDH18A1 (ALDH18A1 Products)

Synonyms: ALDH18A1 antibody, ARCL3A antibody, GSAS antibody, P5CS antibody, PYCS antibody, 2810433K04Rik antibody, AI429789 antibody, Pycs antibody, cb842 antibody, cb899 antibody, pycs antibody, sb:cb881 antibody, wu:fa91f10 antibody, wu:fi05f11 antibody, wu:fi17d12 antibody, aldehyde dehydrogenase 18 family member A1 antibody, aldehyde dehydrogenase 18 family, member A1 antibody, aldehyde dehydrogenase 18 family member A1 L homeolog antibody, ALDH18A1 antibody, aldh18a1 antibody, Aldh18a1 antibody, aldh18a1.L antibody

Background: Defects in ALDH18A1 are the cause of mental retardation-joint hypermobility-skin laxity with or without metabolic abnormalities (MRJHSL) [MIM:612652]. Clinical manifestations include microcephaly, progressive neurologic dysfunction, mental retardation, progeroid appearance, joint hypermobility, skin laxity and hyperelasticity, cataracts. Some patients manifest metabolic disturbances such as hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia.Synonyms: Aldehyde dehydrogenase family 18 member A1, Delta-1-pyrroline-5-carboxylate synthetase, GSAS, P5CS, PYCS

Molecular Weight: 87.3kDa (NP_002851.2).

Gene ID: 5832

NCBI Accession: NP_001017423

UniProt: P54886