anti-TLR4 antibody (Toll-Like Receptor 4)

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Mouse (Murine)
(380), (126), (43), (24), (24), (24), (18), (13), (13), (1), (1)
(219), (214), (25), (8)
Clonality (Clone)
Monoclonal ()
This TLR4 antibody is un-conjugated
(42), (40), (40), (14), (7), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Functional Studies (Func), Flow Cytometry (FACS)
(270), (230), (102), (100), (80), (61), (50), (40), (29), (12), (12), (11), (11), (8), (6), (4), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Immunogen Ba/F3 cell line expressing mouse TLR4 and MD-2 (7)
Clone MTS510
Isotype IgG2a
Specificity This antibody detects CD284 / TLR4. Species Reactivity: Tested: Mouse
Purification Protein G chromatography
Alternative Name CD284 / TLR4 (TLR4 Antibody Abstract)
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa (6).
Alternate names: Toll-like receptor 4
Gene ID 21898
NCBI Accession NP_067272
UniProt Q9QUK6
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, Filter sterilized, Sodium azide free
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Akashi, Shimazu, Ogata et al.: "Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 7, pp. 3471-5, 2000 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Medzhitov, Janeway: "Innate immunity: the virtues of a nonclonal system of recognition." in: Cell, Vol. 91, Issue 3, pp. 295-8, 1997 (PubMed).

Medzhitov, Preston-Hurlburt, Janeway: "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity." in: Nature, Vol. 388, Issue 6640, pp. 394-7, 1997 (PubMed).

Kammeraat, Veldstra: "Characterization of succinate semialdehyde dehydrogenase from rat brain." in: Biochimica et biophysica acta, Vol. 151, Issue 1, pp. 1-10 (PubMed).