Toll-Like Receptor 4 (TLR4) antibody (PE)

Details for Product No. ABIN569714
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Antigen
Synonyms ARMD10, CD284, TLR-4, TOLL, Lps, Ly87, Ran/M1, Rasl2-8
Reactivity
Mouse (Murine)
(206), (68), (30), (20), (20), (18), (13), (9), (1), (1)
Host
Rat
(126), (125), (9), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(25), (22), (14), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(135), (128), (67), (52), (42), (36), (35), (14), (12), (10), (10), (7), (5), (2), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN569714
Quantity 0.1 mg
Price
566.50 $   Plus shipping costs $45.00
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Immunogen Ba/F3 cell line expressing mouse TLR4 and MD-2 (Akashi et al. 2000)
Clone MTS510
Isotype IgG2a
Specificity This antibody detects CD284 / TLR4. Species Reactivity: Tested: Mouse
Purification Protein G chromatography
Alternative Name CD284 / TLR4
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 835 amino acids with approximate molecular weight of 90 kDa (6).
Alternate names: Toll-like receptor 4
Gene ID 21898
NCBI Accession NP_067272.1
UniProt Q9QUK6
Research Area Signaling, Immunology, Inflammation
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody (undiluted) at 2-8°C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
Expiry Date 12 months
Background publications Kammeraat, Veldstra: "Characterization of succinate semialdehyde dehydrogenase from rat brain." in: Biochimica et biophysica acta, Vol. 151, Issue 1, pp. 1-10 (PubMed).

Medzhitov, Preston-Hurlburt, Janeway: "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity." in: Nature, Vol. 388, Issue 6640, pp. 394-7, 1997 (PubMed).

Medzhitov, Janeway: "Innate immunity: the virtues of a nonclonal system of recognition." in: Cell, Vol. 91, Issue 3, pp. 295-8, 1997 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Akashi, Shimazu, Ogata et al.: "Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 7, pp. 3471-5, 2000 (PubMed).

Hosts (126), (125), (9), (5)
Reactivities (206), (68), (30), (20), (20), (18), (13), (9), (1), (1)
Applications (135), (128), (67), (52), (42), (36), (35), (14), (12), (10), (10), (7), (5), (2), (1), (1), (1)
Conjugates (25), (22), (14), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (21), (14), (8), (6), (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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