G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (C-Term) antibody

Antigen: G Protein-Coupled Bile Acid Receptor 1 (GPBAR1)

Synonyms: BG37, GPCR, TGR5, M-BAR, GPCR19, GPR131, MGC40597, GPBAR1, MGC152072, Tgr5, MGC84403, Gpbar1

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN572218

Additional Information

Alternative name: GPCR TGR5 (GPBAR1) (c-terminal region)

Format: Lyophilized

Description: FUNCTION: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. Subcellular location: Cell membrane; Multi-pass membrane protein Also known as: GPBAR, GPBAR1, Membrane-type receptor for bile acids, M-BAR, Tgr5, G protein coupled bile acid receptor 1.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only