Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (C-Term) antibody

Antigen: Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4)

Synonyms: TRPM4B, FLJ20041, LTRPC4, LTrpC-4, AW047689, 1110030C19Rik, Mls2s, trpm4, TRPM4

Epitope: C-Term

Clonality: Polyclonal

Host: Goat

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN572220

Additional Information

Alternative name: TRPM4 (Melastatin-like 2) (c-terminal region)

Format: Lyophilized

Description: FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root andvomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Tissue specificity: Widely expressed. Also known as: Transient receptor potential cation channel subfamily M member 4, Long transient receptor potential channel 4, Calcium-activated non-selective cation channel 1, Melastatin-like 2, MLS2s.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only