YWHAB /14-3-3 Beta (N-Term) antibody

Antigen: YWHAB /14-3-3 Beta (N-Term)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Sheep (Ovine)

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN576194

Additional Information

Swiss-Prot: P31946

Immunogen: Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 beta.

Isotype: IgG  (Matching secondary antibodies)

Description: Gene: YWHAB / 14-3-3 Beta, Standard Gene Symbol: YWHAB, Synonyms: YWHAB, GW128, HS1, Hs1 protein, KCIP-1, YWHAA

Specificity: Recognizes the acetylated N-terminal of 14-3-3 beta. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for it's different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 beta plays a role in the pathogenesis of systemic lupus erythematosus and is involved in negative regulation of p90 ribosomal S6 kinase activity and tuberous sclerosis tumor suppressor proteins. It also binds IGF-1 receptor, RAF1 and CDC25 phosphatases. May not react with recombinant proteins that are not N-acetylated. Predicted Reactivities: Cow (Bovine),Human,Mouse (Murine),Rabbit,Rat (Rattus).

Application Details

Application Notes: ELISA, IHC-P (1:600), WB (1:3000)

Buffer: Serum, 0.09% sodium azide.

Restrictions: For Research Use only