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Integrin beta 2 antibody (PE)

ITGB2 Reactivity: Human, Dog FACS, IHC, IP, IHC (fro), BR Host: Rat Monoclonal PE
Catalog No. ABIN576530
  • Target See all Integrin beta 2 (ITGB2) Antibodies
    Integrin beta 2 (ITGB2)
    Reactivity
    • 191
    • 46
    • 45
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Dog
    Host
    • 101
    • 92
    • 26
    • 2
    Rat
    Clonality
    • 123
    • 93
    • 2
    Monoclonal
    Conjugate
    • 90
    • 24
    • 19
    • 19
    • 10
    • 6
    • 5
    • 5
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    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Integrin beta 2 antibody is conjugated to PE
    Application
    • 120
    • 85
    • 49
    • 47
    • 36
    • 30
    • 26
    • 26
    • 26
    • 25
    • 21
    • 13
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)
    Specificity
    YFC118.3 was clustered at the Fourth International Workshop on Leucocyte Differentiation Antigen (code number N221) as recognizing the CD18 antigen. The CD18 antigen is an integral membrane glycoprotein of 95kD molecular weight - known as the b chain, of the LFA-1 complex. The CD18 antigen is non-covalently linked to CD11a, b, c molecules. The main cellular reactivity of antibody YFC 118.3 is a strong reactivity with Leucocytes (platelets negative). The CD18 Molecule is the receptor for ICAM-1 and is thus important for cell adhesion. YFC118.3 blocks homotypic adhesion and other lymphocyte functions which involve the LFA-1 antigen.
    Purification
    Protein G purified
    Immunogen
    Human neutrophils.

    Type of Immunogen: Cells
    Isotype
    IgG2b
    Top Product
    Discover our top product ITGB2 Primary Antibody
  • Application Notes
    Approved: Block, Flo (1:1), IHC, IHC-Fr, IP

    Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 100 μL whole blood or 10^6 cells in 100 μL. Method sheets are available on request.
    Comment

    Target Species of Antibody: Human

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Distilled Water.
    Concentration
    Lot specific
    Buffer
    Lyophilized, PBS,  pH 7.2, 0.09 % sodium azide, 1 % BSA.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Target
    Integrin beta 2 (ITGB2)
    Alternative Name
    ITGB2 / MAC-1 / CD18 (ITGB2 Products)
    Synonyms
    CD18 antibody, LAD antibody, LCAMB antibody, LFA-1 antibody, MAC-1 antibody, MF17 antibody, MFI7 antibody, 2E6 antibody, AI528527 antibody, Cd18 antibody, Lfa1 antibody, ITGB2 antibody, itgb2 antibody, itgb2-a antibody, itgb2-b antibody, integrin subunit beta 2 antibody, integrin beta 2 antibody, integrin subunit beta 2 S homeolog antibody, ITGB2 antibody, Itgb2 antibody, itgb2.S antibody
    Background
    Name/Gene ID: ITGB2
    Family: Integrin

    Synonyms: ITGB2, CD18 antigen, CD18, Integrin beta chain, beta 2, LCAMB, MAC-1, MFI7, MF17, Integrin beta-2, LAD, LFA-1
    Gene ID
    3689
    UniProt
    P05107
    Pathways
    NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
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