CD46 antibody (PE)

Catalog No. ABIN610111

Product Details anti-CD46 Antibody (PE)

Target: CD46

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS), Functional Studies (Func)

Specificity: SCR1 epitope of CD46.

Purification: Gel filtration

Immunogen: Human PBL and EBV transformed LCL.

Clone: 169-1-EA-3

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo, Func, WB

Usage: Function: Does not block MCP function. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 500 mM potassium chloride, 150 mM sodium chloride, 15 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Product is photosensitive and should be protected from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

References for anti-CD46 antibody (PE) (ABIN610111)

Saucier, Papavasiliou, Palazzo, Naujokas, Kremer, Park: "Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis." in: Oncogene, Vol. 21, Issue 12, pp. 1800-11, (2002) (PubMed).

Elowe, Holland, Kulkarni, Pawson: "Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction." in: Molecular and cellular biology, Vol. 21, Issue 21, pp. 7429-41, (2001) (PubMed).

Miki, Miura, Matuoka, Nakata, Hirokawa, Orita, Kaibuchi, Takai, Takenawa: "Association of Ash/Grb-2 with dynamin through the Src homology 3 domain." in: The Journal of biological chemistry, Vol. 269, Issue 8, pp. 5489-92, (1994) (PubMed).

Target Details for CD46

Target: CD46

Alternative Name: MCP / CD46 (CD46 Products)

Synonyms: AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody

Background: Name/Gene ID: CD46

Synonyms: CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein

Gene ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization