CD70 antibody

Catalog No. ABIN610194

Product Details anti-CD70 Antibody

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD70 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Functional Studies (Func)

Specificity: CD70 Molecule of approximately 30 kd.

Purification: Protein A purified

Immunogen: Human WM-1 (Waldenstrpm's macroglobulinemia) cell line.

Clone: BU69

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, Flo, Func, ICC, IHC, IHC-Fr

Usage: Function: Blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 0.5 mg/mL Gentamicin sulfate

Preservative: Gentamicin sulfate

Precaution of Use: This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

References for anti-CD70 antibody (ABIN610194)

Baki, Marambaud, Efthimiopoulos, Georgakopoulos, Wen, Cui, Shioi, Koo, Ozawa, Friedrich, Robakis: "Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2381-6, (2001) (PubMed).

Huan, van Adelsberg: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." in: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, (1999) (PubMed).

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70 (CD70 Products)

Synonyms: CD27LG antibody, Cd27l antibody, Tnfsf7 antibody, CD27L antibody, TNFSF7 antibody, CD70 antigen antibody, CD70 molecule antibody, Cd70 molecule antibody, Cd70 antibody, CD70 antibody

Background: Name/Gene ID: CD70
Family: TNF

Synonyms: CD70, CD27LG, Ki-24 antigen, Surface antigen CD70, CD27 ligand, CD27-L, CD70 antigen, CD70 Molecule, TNFSF7

Gene ID: 970

UniProt: P32970

Pathways: Cancer Immune Checkpoints