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PDE8A antibody (AA 551-600)

PDE8A Reactivity: Human, Rat, Monkey, Rabbit, Dog, Horse, Cow, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6746531
  • Target See all PDE8A Antibodies
    PDE8A (phosphodiesterase 8A (PDE8A))
    Binding Specificity
    • 17
    • 13
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 551-600
    Reactivity
    • 52
    • 11
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Rat, Monkey, Rabbit, Dog, Horse, Cow, Guinea Pig
    Host
    • 48
    • 4
    Rabbit
    Clonality
    • 49
    • 3
    Polyclonal
    Conjugate
    • 25
    • 7
    • 7
    • 5
    • 4
    • 4
    This PDE8A antibody is un-conjugated
    Application
    • 35
    • 33
    • 32
    • 8
    • 8
    • 7
    • 6
    • 6
    • 1
    Western Blotting (WB)
    Specificity
    Human PDE8A
    Predicted Reactivity
    Percent identity by BLAST analysis: Human, Dog, Bovine, Rabbit, Horse, Guinea pig (100%) Mouse, Rat, Chicken, Zebrafish (92%).
    Purification
    Immunoaffinity purified
    Immunogen
    Synthetic peptide located between aa551-600 of human PDE8A (O60658, NP_002596). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Rat, Dog, Bovine, Rabbit, Horse, Guinea pig (100%), Mouse, Elephant, Pig, Opossum, Turkey, Zebra finch, Chicken, Xenopus, Zebrafish (92%), Marmoset, Bat (85%), Platypus, Drosophila (84%), Bloom alga (83%).

    Type of Immunogen: Synthetic peptide
    Top Product
    Discover our top product PDE8A Primary Antibody
  • Application Notes
    Approved: WB (0.2 - 1 μg/mL)

    Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.
    Comment

    Target Species of Antibody: Human

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Distilled water
    Concentration
    Lot specific
    Buffer
    Lyophilized from PBS with 2 % sucrose
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment
    Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
    Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
  • Shahan, Sorenson, Simpson, Kefalides, Lewis: "Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages." in: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10175-81, (2000) (PubMed).

    Yang, Malek, Desiderio: "An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo." in: The Journal of biological chemistry, Vol. 270, Issue 35, pp. 20832-40, (1995) (PubMed).

    Aoki, Isselbacher, Pillai: "Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 22, pp. 10606-9, (1994) (PubMed).

    Vetrie, Vorechovský, Sideras, Holland, Davies, Flinter, Hammarström, Kinnon, Levinsky, Bobrow: "The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases." in: Nature, Vol. 361, Issue 6409, pp. 226-33, (1993) (PubMed).

  • Target
    PDE8A (phosphodiesterase 8A (PDE8A))
    Alternative Name
    PDE8A (PDE8A Products)
    Synonyms
    PDE8A antibody, Pde8a antibody, HsT19550 antibody, AI551852 antibody, Pde8 antibody, RNPDE8A antibody, phosphodiesterase 8A antibody, PDE8A antibody, Pde8a antibody, pde8a antibody
    Background
    Name/Gene ID: PDE8A
    Subfamily: PDE - cAMP-specific, high affinity
    Family: Phosphodiesterase

    Synonyms: PDE8A, Phosphodiesterase 8A, HsT19550
    Gene ID
    5151
    NCBI Accession
    NP_002596
    UniProt
    O60658
    Pathways
    cAMP Metabolic Process
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