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PDE8A antibody (phosphodiesterase 8A) (AA 681-730)

Details for Product anti-PDE8A Antibody No. ABIN611117, Supplier: Log in to see
Antigen
  • PDE8A
  • Pde8a
  • HsT19550
  • AI551852
  • Pde8
  • RNPDE8A
  • phosphodiesterase 8A
  • phosphodiesterase 8a
  • PDE8A
  • Pde8a
  • pde8a
  • LOC100223556
  • LOC100343099
Alternatives
anti-Human PDE8A antibody for Immunoprecipitation
Epitope
AA 681-730
28
18
10
9
9
7
3
3
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Monkey, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
72
13
12
10
4
4
4
3
1
1
1
1
Host
Rabbit
64
8
Clonality
Polyclonal
Conjugate
This PDE8A antibody is un-conjugated
7
4
4
4
4
4
Application
Western Blotting (WB)
46
40
38
14
10
8
8
6
1
Options
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Immunogen Synthetic peptide located between aa681-730 of human PDE8A (O60658, NP_775656). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Galago, Mouse, Rat, Elephant, Bovine, Rabbit, Pig (100%), Dog, Horse, Guinea pig, Zebrafish (92%), Xenopus, Drosophila (91%), Marmoset, Bat, Opossum, Turkey, Zebra finch, Chicken, Lizard, Stickleback (85%).

Type of Immunogen: Synthetic peptide
Specificity Human PDE8A
Predicted Reactivity Percent identity by BLAST analysis: Human, Mouse, Rat, Bovine, Rabbit (100%) Dog, Horse, Guinea pig, Zebrafish (92%) Chicken (85%).
Purification Immunoaffinity purified
Alternative Name PDE8A (PDE8A Antibody Abstract)
Background Name/Gene ID: PDE8A
Subfamily: PDE - cAMP-specific, high affinity
Family: Phosphodiesterase

Synonyms: PDE8A, Phosphodiesterase 8A, HsT19550
Gene ID 5151
NCBI Accession NP_775656
UniProt O60658
Research Area Signaling, Enzymes, Metabolism
Pathways cAMP Metabolic Process
Application Notes Approved: WB (0.2 - 1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Distilled water
Concentration Lot specific
Buffer Lyophilized from PBS with 2 % sucrose
Handling Advice Avoid repeat freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles.
Supplier Images
 image for anti-PDE8A antibody (phosphodiesterase 8A) (AA 681-730) (ABIN611117) anti-phosphodiesterase 8A (PDE8A) (AA 681-730) antibody
Product cited in: Shahan, Sorenson, Simpson, Kefalides, Lewis: "Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages." in: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10175-81, 2000 (PubMed).

Yang, Malek, Desiderio: "An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo." in: The Journal of biological chemistry, Vol. 270, Issue 35, pp. 20832-40, 1995 (PubMed).

Aoki, Isselbacher, Pillai: "Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 22, pp. 10606-9, 1994 (PubMed).

Vetrie, Vorechovský, Sideras, Holland, Davies, Flinter, Hammarström, Kinnon, Levinsky, Bobrow: "The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases." in: Nature, Vol. 361, Issue 6409, pp. 226-33, 1993 (PubMed).