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Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C) antibody
|Synonyms||Cdc25, CDC25C, CDC25, cdc25, xcdc25c|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1ml (1. 000mg/ml)|
|Price||546.86 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 8 to 9 Business Days|
|Immunogen||Purified recombinant fragment of human CD14 expressed in E. Coli.|
Synonyms: CDC25, CDC25C.
Cdc25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It has been highly conserved during evolution and it plays a key role in the regulation of cell division. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Cdc25C is mainly expressed in G2 phase. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
|Specificity||Rabbit polyclonal to PADI4|
|Application Notes||WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ELISA: 1/10000|
|Preservative||0.03% sodium azide|
|Storage||Store at 4°C, for long term storage, store at -20°C|
|Research Area||Cell Cycle|
|Restrictions||For Research Use only|
|PADI4 antibody at 1/1000 dilution, Lane 1: 293 whole cell lysates, Lane 2: Hela whole cell lysates, Predicted band size: 74kDa, Observed band size: 74kDa Additional band size:37kDa|
Vecchione, Baldassarre, Ishii et al.: "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development." in: Cancer cell, Vol. 11, Issue 3, pp. 275-89, 2007 (PubMed).
Busch, Barton, Morgenstern et al.: "The G2/M checkpoint phosphatase cdc25C is located within centrosomes." in: The international journal of biochemistry & cell biology, Vol. 39, Issue 9, pp. 1707-13, 2007 (PubMed).
Zheng, Kosti, Loffredo et al.: "Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 9, pp. 2199-210, 2010 (PubMed).