BIRC3 antibody (Internal Region)

Catalog No. ABIN615619

Product Details anti-BIRC3 Antibody

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Binding Specificity: AA 109-118, Internal Region

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This BIRC3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-SQPTFPSSVT

Specificity: Recognizes BIRC3 (109-118)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_001156.1. Genename: BIRC3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BIRC3

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Alternative Name: IAP1 / BIRC3 (BIRC3 Products)

Background: CIAP2 is an apoptotic suppressor. Apoptosis is triggered by a variety of stimuli including members of the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of cIAP (cIAP1 and cIAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The cIAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF alpha by its receptor. Omi, a negative regulator of cIAP, inhibits its activity by catalytically cleaving cIAP. Another negative regulator, Smac/DIABLO, acts by enhancing the autoubiquitization activity of cIAP.Synonyms: API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing protein 3, C-IAP2, HIAP-1, IAP homolog C, Inhibitor of apoptosis protein 1, MIHC, RING finger protein 49, RNF49, TNFR2-TRAF-signaling complex protein 1, cIAP2

Gene ID: 330

NCBI Accession: NP_001156

UniProt: Q13489

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades