Neurogranin antibody (Internal Region)

Catalog No. ABIN615919

Product Details anti-Neurogranin Antibody

Target: Neurogranin (NRGN)

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This Neurogranin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: C-KIKSGERGRK G

Specificity: This antibody recognizes Neurogranin. Reported variants represent identical protein: NP_006167.1, NP_001119653.1

Cross-Reactivity (Details): Species reactivity (expected):Canine (Dog) and Bovine.
Species reactivity (tested):Human, Mouse and Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_006167.1. Genename: NRGN

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Neurogranin

Target: Neurogranin (NRGN)

Alternative Name: Neurogranin (NRGN Products)

Synonyms: RC3 antibody, hng antibody, 0710001B06Rik antibody, AI838505 antibody, NG antibody, NG/RC3 antibody, Pss1 antibody, R75334 antibody, zgc:158686 antibody, neurogranin antibody, neurogranin (protein kinase C substrate, RC3) b antibody, NRGN antibody, Nrgn antibody, nrgnb antibody

Background: Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.Synonyms: Ng, Nrgn, Protein kinase C substrate 7.5 kDa protein, RC3

Gene ID: 4900

NCBI Accession: NP_006167

UniProt: Q92686