BST2 antibody (Internal Region)

Catalog No. ABIN615955

Product Details anti-BST2 Antibody

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Binding Specificity: Internal Region

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This BST2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-ELTEAQKGFQ D

Specificity: Recognizes CD317 / BST2

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence, from the internal region of the protein sequence according to NP_004326.1. Genename: BST2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Alternative Name: CD317 / BST2 (BST2 Products)

Synonyms: BST2 antibody, CD317 antibody, TETHERIN antibody, 2310015I10Rik antibody, Bst-2 antibody, C87040 antibody, DAMP-1 antibody, GREG antibody, Damp1 antibody, bone marrow stromal cell antigen 2 antibody, bone marrow stromal antigen 2 antibody, BST2 antibody, LOC618737 antibody, Bst2 antibody

Background: Bone marrow stromal Antigen-2 (BST-2) is a 30- to 36- kDa type II transmembrane protein, consisting of 180 amino acids. It has been shown to form a complex with Rho-GTPase activating protein, RICH2 (1). This complex is essential for the organization of subapical actin cytoskeleton. BST-2 protein is expressed on certain bonemarrow stromal cell lines and on various normal tissues. The expression pattern of BST2 is relatively different form another bone marrow stromal antigen 1 (BST1). The BST-2 gene is located on chromosome 19p13.2. BST-2 surface expression on fibroblast cell lines facilitated the stromal cell-dependent growth of a murine bone marrow-derived pre-B-cell line, DW34. Some studies suggest that BST-2 may be involved in pre-B-cell growth development by regulating their surface molecules and cytokines (2). BST2 is also expressed in synovial cell lines from where the BST2 gene was cloned. BST2 is predominantly expressed in liver, lungs, heart, placenta and lower levels in pancreas, kidney, skeletal muscle and brain. Naturally all human cells possess an antiviral activity that inhibits the release of retrovirus particles, and other enveloped virus particles. This antiviral activity is antagonized by the HIV-1 accessory protein, Vpu. The antiviral activity can be constitutively induced and expressed by interferon-alfa and is consist of protein based Synonyms: BST-2, Bone marrow stromal antigen 2, HM1.24 antigen, Tetherin

Gene ID: 684

NCBI Accession: NP_004326

UniProt: Q10589

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response