CLCN2 antibody (Internal Region)

Catalog No. ABIN615956

Product Details anti-CLCN2 Antibody

Target: CLCN2 (Chloride Channel 2 (CLCN2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This CLCN2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: QQLDEPVNFS DCK

Specificity: This antibody is expected to recognize all reported isoforms (NP_004357.3, NP_001164558.1, NP_001164559.1, NP_001164560.1).

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog), Cow, Rabbit .
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_004357.3. Genename: CLCN2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CLCN2

Target: CLCN2 (Chloride Channel 2 (CLCN2))

Alternative Name: CLCN2 (CLCN2 Products)

Synonyms: CLCN2 antibody, CLC2 antibody, LOC100150892 antibody, AL118368 antibody, ClC-2 antibody, Clc2 antibody, nmf240 antibody, CLC-2 antibody, CIC-2 antibody, ECA2 antibody, ECA3 antibody, EGI11 antibody, EGI3 antibody, EGMA antibody, EJM6 antibody, EJM8 antibody, clC-2 antibody, chloride voltage-gated channel 2 antibody, chloride channel, voltage-sensitive 2a antibody, chloride channel protein 2 antibody, chloride channel, voltage-sensitive 2 antibody, CLCN2 antibody, clcn2a antibody, EHI_142170 antibody, EHI_186860 antibody, Clcn2 antibody

Background: CLCN2 is a voltage-gated chloride channel, a class of proteins that have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This protein is ubiquitously expressed, with moderate expression in aortic and coronary vascular smooth muscle cells and low levels expressed in aortic endothelial cells. Defects in CLCN2 may be the cause of epilepsy with grand mal seizures on awakening, childhood absence epilepsy type 3, and juvenile absence epilepsy. Single nucleotide polymorphisms (SNPs) of CLCN2 may also at as potential modifiers of cystic fibrosis disease severity.Synonyms: CIC-2, CIC2, CLC3, Chloride channel protein 2

Gene ID: 1181

NCBI Accession: NP_001164558

UniProt: P51788