GM2A antibody (Internal Region)

Catalog No. ABIN615967

Product Details anti-GM2A Antibody

Target: GM2A (GM2 Ganglioside Activator (GM2A))

Binding Specificity: AA 164-175, Internal Region

Reactivity: Human, Mouse, Rat, Rabbit

Host: Goat

Clonality: Polyclonal

Conjugate: This GM2A antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-TTGNYRIESV LS

Specificity: This antibody is expected to recognize isoform 1 (NP_000396.2) only.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rabbit.
Species reactivity (tested):Human, Rat.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence (aa 164-175) from the internal region of the protein sequence according to NP_000396.2. Genename: GM2A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GM2A

Target: GM2A (GM2 Ganglioside Activator (GM2A))

Alternative Name: GM2A / SAP3 (GM2A Products)

Synonyms: GM2A antibody, fb96e04 antibody, fb96e10 antibody, wu:fb96e04 antibody, wu:fb96e10 antibody, zgc:110188 antibody, MGC84154 antibody, GM2-AP antibody, SAP-3 antibody, AA408702 antibody, AW215435 antibody, GM2 ganglioside activator antibody, GM2 ganglioside activator L homeolog antibody, GM2 ganglioside activator protein antibody, Gm2a antibody, GM2A antibody, gm2a antibody, gm2a.L antibody

Background: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease.Synonyms: Cerebroside sulfate activator protein, GM2-AP, Ganglioside GM2 activator, Shingolipid activator protein 3

Gene ID: 2760

NCBI Accession: NP_000396

UniProt: P17900