Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) (pSer362), (pThr360) antibody

Details for Product No. ABIN616047, Supplier: Log in to see
Antigen
  • CSNK2A1
  • csnk2a1
  • CK2A
  • CK2
  • Ck2a
  • BmCK2a
  • Ckiialpha
  • CK-II
  • CK2A1
  • CKII
  • CSNK2A3
  • Csnk2a1-rs4
  • ck2a1
  • CK2A2
  • 1110035J23Rik
  • C77789
  • casein kinase 2, alpha 1 polypeptide
  • casein kinase 2 alpha subunit
  • CK2 protein kinase alpha 2
  • casein kinase II alpha subunit
  • Casein kinase II alpha subunit
  • casein kinase 1, alpha 1
  • casein kinase 2, alpha prime polypeptide
  • CSNK2A1
  • csnk2a1
  • CK2A
  • cka2
  • Ck2a
  • Ckiialpha
  • LOC100360989
  • CK2A1
  • CSNK1A1
  • Csnk2a1
  • CSNK2A2
  • Csnk2a2
Epitope
pThr360, pSer362
14
13
11
5
5
4
4
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
132
70
60
8
7
7
6
5
5
3
3
3
2
2
2
2
1
1
Host
Rabbit
114
20
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
109
49
37
21
15
13
9
4
3
3
1
1
Options
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Immunogen Peptide sequence around phosphorylation site of Threonine 360/Serine 362
Sequence V-P-T(p)-P-S(p)-P-L
Specificity This antibody detects endogenous level of CK2 only when phosphorylated at thronine 360.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat
Purification Affinity Chromatography using epitope-specific peptide
Alternative Name Casein Kinase II Subunit alpha (CSNK2A1 Antibody Abstract)
Background Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.Synonyms: CK II alpha, CK2A1, CSNK2A1
Molecular Weight 42 kDa
Gene ID 1457
NCBI Accession NP_001886
UniProt P68400
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) (pSer362), (pThr360) antibody (ABIN616047) Western blot of CK2α(Phospho- Thr360/Ser362) antibody and CK2α antibody in vitro kina...
Background publications Trembley, Tatsumi, Sakashita, Loyer, Slaughter, Suzuki, Endo, Kidd, Mayeda: "Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1446-57, 2005 (PubMed).

Keller, Lu: "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 50206-13, 2002 (PubMed).

Niefind, Guerra, Ermakowa, Issinger: "Crystallization and preliminary characterization of crystals of human protein kinase CK2." in: Acta crystallographica. Section D, Biological crystallography, Vol. 56, Issue Pt 12, pp. 1680-4, 2001 (PubMed).

Keller, Zeng, Wang, Zhang, Kapoor, Shu, Goodman, Lozano, Zhao, Lu: "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1." in: Molecular cell, Vol. 7, Issue 2, pp. 283-92, 2001 (PubMed).