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CD19 antibody

CD19 Reactivity: Mouse FACS, IP, IHC (fro), Func Host: Rat Monoclonal 1D3 unconjugated
Catalog No. ABIN616757
  • Target See all CD19 Antibodies
    CD19 (CD19 Molecule (CD19))
    Reactivity
    • 294
    • 162
    • 48
    • 30
    • 19
    • 10
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
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    • 2
    • 2
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    • 2
    • 2
    Mouse
    Host
    • 172
    • 141
    • 47
    • 4
    Rat
    Clonality
    • 232
    • 128
    • 2
    Monoclonal
    Conjugate
    • 113
    • 22
    • 21
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    • 16
    • 8
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    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
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    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD19 antibody is un-conjugated
    Application
    • 263
    • 117
    • 72
    • 62
    • 60
    • 40
    • 23
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    • 14
    • 14
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Specificity
    This antibody detects detects mouse CD19, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells, it is lost on plasma cells.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Protein-G affinity chromatography
    Endotoxin Level
    Less than 10 EU/mg of the protein, as determined by the LAL test
    Immunogen
    Mouse CD19-transfected cell line
    Clone
    1D3
    Isotype
    IgG2a
    Top Product
    Discover our top product CD19 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Azide free PBS, pH ~7.4
    Preservative
    Azide free
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD19 (CD19 Molecule (CD19))
    Alternative Name
    CD19 (CD19 Products)
    Synonyms
    B4 antibody, CVID3 antibody, AW495831 antibody, CD19 antibody, CD19 molecule antibody, CD19 antigen antibody, CD19 antibody, Cd19 antibody
    Background
    CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
    Gene ID
    12478
    NCBI Accession
    NP_033974
    UniProt
    P25918
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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