COL1A1 antibody (C-Term)

Catalog No. ABIN617243

Product Details anti-COL1A1 Antibody

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PPGPPSAGFD FSFLPQPPQE KAHDGGRYYR ADDANVVRDR DLEVDTTLKS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 92%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against COL1A1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human COL1A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1464 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COL1A1

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Alternative Name: COL1A1 (COL1A1 Products)

Synonyms: OI4 antibody, Col1a-1 antibody, Cola-1 antibody, Cola1 antibody, Mov-13 antibody, Mov13 antibody, COLIA1 antibody, col1a1 antibody, MGC52532 antibody, COL1A1 antibody, COL1A2 antibody, alpha1(I) antibody, cb21 antibody, sb:cb21 antibody, sb:cb384 antibody, wu:fa99c12 antibody, wu:fb02c06 antibody, alpha3(I) antibody, col1a3 antibody, hm:zeh0348 antibody, wu:fa95h05 antibody, wu:fd02a10 antibody, wu:fj59a10 antibody, collagen type I alpha 1 chain antibody, collagen, type I, alpha 1 antibody, collagen, type I, alpha 1 S homeolog antibody, collagen alpha-1(I) chain antibody, collagen type I alpha 2 chain antibody, collagen, type I, alpha 1a antibody, collagen 1a1 antibody, collagen, type I, alpha 1b antibody, COL1A1 antibody, Col1a1 antibody, col1a1.S antibody, LOC397571 antibody, COL1A2 antibody, col1a1a antibody, col1a1 antibody, col1a1b antibody

Background: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Alias Symbols: OI4
Protein Interaction Partner: PDGFB, PDGFA, COL1A2, COL1A1, CAPN1, UBC, BRCA1, BARD1, C12orf57, RNH1, ATP13A2, ELAVL1, ACHE, TMPRSS6, P4HB, PAK1, HTRA1, MATN2, PRELP, TGFBI, BGN, VWF, ITGA2, DDR2, THBS1, TXN, SPARC, CD36, FGF7, IGFBP3, ITGA5, FN1, NID1, DCN, CD93, MMP9, MMP2, COL7A1,
Protein Size: 1464

Molecular Weight: 137 kDa

Gene ID: 1277

NCBI Accession: NM_000088, NP_000079

UniProt: P02452

Pathways: Sensory Perception of Sound, Autophagy, Growth Factor Binding