H2AFY2 antibody (Middle Region)

Catalog No. ABIN630682

Product Details anti-H2AFY2 Antibody

Target: H2AFY2 (H2A Histone Family, Member Y2 (H2AFY2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H2AFY2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: H2 AFY2 antibody was raised against the middle region of H2 FY2

Purification: Affinity purified

Immunogen: H2 AFY2 antibody was raised using the middle region of H2 FY2 corresponding to a region with amino acids KKGGKKSKAAKPRTSKKSKPKDSDKEGTSNSTSEDGPGDGFTILSSKSLV

Application Details

Application Notes: WB: 1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

H2AFY2 Blocking Peptide, catalog no. 33R-4465, is also available for use as a blocking control in assays to test for specificity of this H2AFY2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of H0 FY2 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Target Details for H2AFY2

Target: H2AFY2 (H2A Histone Family, Member Y2 (H2AFY2))

Alternative Name: H2AFY2 (H2AFY2 Products)

Synonyms: macroH2A2 antibody, RGD1561371 antibody, MGC69037 antibody, MGC130768 antibody, macroh2a2 antibody, im:6898017 antibody, wu:fa14g05 antibody, zgc:114051 antibody, H2AFY2 antibody, H2A histone family member Y2 antibody, H2A histone family, member Y2 antibody, H2A histone family member Y2 L homeolog antibody, core histone macro-H2A.2 antibody, H2AFY2 antibody, H2afy2 antibody, h2afy2.L antibody, h2afy2 antibody, LOC100224559 antibody, LOC100343925 antibody, LOC100456998 antibody, LOC489024 antibody, LOC100738475 antibody

Background: H2AFY2 is the variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2AFY2 may be involved in stable X chromosome inactivation.

Molecular Weight: 40 kDa (MW of target protein)