Adipolean Variant antibody

Antigen: Adipolean Variant

Clonality: Polyclonal

Host: Rabbit

Application: ELISA, Blocking Antibody (Inhibition), Western Blotting (WB)

Catalog no.: ABIN636638

Additional Information

Immunogen: Adipolean Variant antibody was raised in rabbit using highly pure recombinant human adipolean variant as the immunogen.

Description: The adipolean variant is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. The adipolean variant antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It also inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway.

Application Details

Purity: Affinity Purified

Buffer: Lyophilized from PBS, pH 7.2.

Storage: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C. Avoid repeated freeze/thaw cycles.