Anthrax Lethal Factor antibody

Antigen: Anthrax Lethal Factor

Host: Mouse

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN639881

Additional Information

Characteristics: Mouse Anti-Anthrax Lethal Factor

Immunogen: Highly purified Bacillus anthracis lethal factor.

Isotype: IgG2a  (Matching secondary antibodies)

Specificity: DS-MB-02602 recognizes the Lethal Factor of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The LF acts as an endoprotease, removing the N-terminus of mitogen-activated protein kinase kinases (MAPKK). The kinases are prevented from binding to their substrates, which leads to altered signaling pathways and ultimately to apoptosis. DS-MB-02602 has been used to detect the Lethal Factor of Bacillus anthracis in ELISA assays as a detection antibody.

Application Details

Concentration: IgG concentration 1.0 mg/ml

Purification: Purified

Buffer: Phosphate buffered saline pH7.4

Preservative: 0.09% Sodium Azide (NaN 3 )

Storage: Store at +4 ° C or at -20 ° C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of shipment

Research Area: Virology

Restrictions: For Research Use only