tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, zeta Polypeptide (YWHAZ) antibody

Antigen: tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, zeta Polypeptide (YWHAZ)

Synonyms: KCIP-1, MGC111427, MGC126532, MGC138156, 14-3-3-zeta, AI596267, AL022924, AU020854, 1110013I11Rik, 14-3-3z, YWHAZ, ywhaz, ywhazb, MGC64423, ywhaza, MGC52760, 14-3-3zeta, ywhaq, kcip-1, MGC75570, Ywhaz, ACYPI003154, DKFZp459E1224, 1433z

Host: Rabbit

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN640711

Additional Information

Characteristics: Rabbit Anti-14-3-3 zeta

Alternative name: 14-3-3 zeta

Immunogen: Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 zeta.

Sequence: Ac.MDKNELVQKAC

Format: Serum

Isotype: IgG  (Matching secondary antibodies)

Specificity: DS-PB-00014 recognizes the acetylated N-terminal of 14-3-3 zeta in all mammals. It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha. This antibody reacts with Bovine, Chicken, Rat, Human and Mouse. Antibody reactivity and working conditions may vary between species. DS-PB-00014 may not react with recombinant proteins that are not N-acetylated.

Synonyms: KCIP-1, MGC111427, MGC126532, MGC138156, 14-3-3-zeta, AI596267, AL022924, AU020854, 1110013I11Rik, 14-3-3z, YWHAZ, ywhaz, ywhazb, MGC64423, ywhaza, MGC52760, 14-3-3zeta, ywhaq, kcip-1, MGC75570, Ywhaz, ACYPI003154, DKFZp459E1224, 1433z

Application Details

Preservative: 0.09% Sodium Azide

Storage: Store at +4 ° C or at -20 ° C if preferred.

Research Area: Alzheimer's Disease, Apoptosis/Necrosis, Wnt

Restrictions: For Research Use only