CD274 Molecule (CD274) antibody

Antigen: CD274 Molecule (CD274)

Synonyms: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, MGC142294, MGC142296, B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik, CD274

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS)

Catalog no.: ABIN641864

Additional Information

Characteristics: Mouse Anti-Human CD274

Alternative name: CD274

Immunogen: Human CD274 transfected P815 cells

Isotype: IgG1  (Matching secondary antibodies)

Description: Synonyms: B7H1, PDCD1L1, PDCD1LG1, PDL1

Specificity: DS-MB-02960 detects human CD274, also known as B7-H1and PD-1L,a cell surface glycoprotein which is a member of the B7 family of costimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma. CD274 is reported to possess dual functions, inhibition of activated effector T-cells and costimulation of naive T-cells. CD274 inhibits proliferation of activated T-cells via ligation to the coinhibitory molecule CD279 (programmed death-1, PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T-cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.

Application Details

Concentration: IgG concentration 1.0 mg/ml

Purification: Purified

Buffer: Phosphate buffered saline pH7.4

Preservative: 0.09% Sodium Azide (NaN3)

Storage: Store at +4 ° C or at -20 ° C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of shipment

Research Area: Immunology, CD Antigens

Restrictions: For Research Use only