CD274 Molecule (CD274) antibody

Antigen: CD274 Molecule (CD274)

Synonyms: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, MGC142294, MGC142296, B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik, CD274

Host: Rat

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)

Catalog no.: ABIN643006

Additional Information

Characteristics: Rat Anti-Mouse CD274

Alternative name: CD274

Immunogen: Mouse CD274 - transfected L5178Y cells

Isotype: IgG2a  (Matching secondary antibodies)

Description: Synonyms: B7H1, PDCD1L1, PDCD1LG1, PDL1

Specificity: DS-MB-03793 detects mouse CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma. CD274 is reported to possess dual functions, inhibition of activated effector T cells and co-stimulation of naive T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1, PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.

Application Details

Concentration: IgG concentration 1.0 mg/ml

Purification: Purified

Buffer: Phosphate buffered saline pH7.4

Preservative: 0.09% Sodium Azide (NaN 3 )

Storage: Store at +4 ° C or at -20 ° C if preferred.

Research Area: Immunology, CD Antigens

Restrictions: For Research Use only