Lymphocytic Choriomeningitis Virus (LCMV) antibody

Antigen: Lymphocytic Choriomeningitis Virus (LCMV)

Host: Mouse

Application: Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)

Catalog no.: ABIN643438

Additional Information

Characteristics: Mouse Anti-Lymphocytic Choriomeningitis Virus (LCMV)

Immunogen: KCMV isolated from human HeLa cells

Format: Supernatant

Isotype: IgG1  (Matching secondary antibodies)

Description: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is the fundamental enzyme of prostaglandin degradation. PGDH, an ubiquitous enzyme, strongly reduces the biologic activity of these molecules by catalyzing the oxidation of the 15-hydroxyl group of prostaglandins to a keto group. Cortisol reduces PGDH activity in human placental cells. 11-beta- hydroxysteroid dehydrogenase type II (HSD11B2) converts cortisol to cortisone. In preeclampsia, a disorder characterized by high blood pressure and protein in the urine during pregnancy and the postpartum period, HSD11B2 mRNA expression is reduced, leading to a decrease in HSD11B2 activity. Therefore, the diminished conversion of placental cortisol may lead to reduced PGDH mRNA expression by means of an autocrine or paracrine mechanism.

Specificity: Reacts with LCMV-infected cells (e.g. Vero, HeLa). Reacts with Human and mouse.

Application Details

Buffer: Not applicable

Preservative: 0.09% Sodium azide

Storage: Store at 2-8°C. Centrifuge before opening to ensure complete recovery of vial contents.

Restrictions: For Research Use only