Glutamate Receptor, Metabotropic 2/3 (GRM2/GRM3) antibody

Antigen: Glutamate Receptor, Metabotropic 2/3 (GRM2/GRM3)

Host: Rabbit

Reactivity: Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Catalog no.: ABIN644738

Additional Information

Characteristics: Rabbit Anti-Rat Metabotropic Glutamate Receptor 2/3

Alternative name: Metabotropic Glutamate Receptor 2/3

Immunogen: Peptide from the C-terminal region of rat mGluR2 and rat mGluR3.

Cross-Reactivity: Human, Cow (Bovine), Fish, Mouse (Murine), Rabbit, Dog (Canine)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonyms: GPRC1B, GPRC1C, MGLUR2, MGLUR3

Specificity: DS-PB-02909 recognizes rat metabotropic glutamate receptor 2 and 3 (mGluR2 and mGluR3). The metabotropic glutamate receptors have been organized into three groups, mGluR2 and mGluR3 make up group II, and are negatively coupled to adenylate cyclase. Group II mGluRs act to inhibit neurotransmitter release as auto receptors on glutamatergic terminals and as presynaptic heteroreceptors, performing a variety of functions in the central and peripheral nervous system. Studies have shown that mGluRs play an important role in neuroplasticity and group II mGluRs are targeted by various drugs used for treating anxiety, Parkinson's disease, schizophrenia and drug addiction. DS-PB-02909 detects bands of approximately 110kDa (monomer) and 220kDa (dimer) in rat hippocampal lysates.(Western Blotting test)

Application Details

Purification: Purified

Buffer: 200mM Tris-Glycine pH7.5

Preservative: 0.09% Sodium Azide (NaN3)

Storage: Store at 4 ° C or at -20 ° C if preferred.

Restrictions: For Research Use only