PYCARD antibody

Catalog No. ABIN645848

Product Details anti-PYCARD Antibody

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Reactivity: Human

Host: Goat

Conjugate: This PYCARD antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Peptide ELISA: Antibody detection limit dilution 1:32,000. Western Blot: Approx. 22kDa band observed in Hela and Human Kidney lysates (predicted MW of 22kDa according to NP_037390.2). Recommended for use at 1-3µg/ml.

Cross-Reactivity: Human

Characteristics: Goat Anti-ASC / TMS1

Immunogen: Peptide with sequence C-RESQSYLVEDLERS, from the C Terminus of the protein sequence according to NP_037390.2, NP_660183.1, NP_660184.1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-PYCARD antibody (ABIN645848)

Ansari, Dutta, Veettil, Dutta, Iqbal, Kumar, Roy, Chikoti, Singh, Chandran: "Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses." in: PLoS pathogens, Vol. 11, Issue 7, pp. e1005019, (2015) (PubMed).

Singh, Kerur, Bottero, Dutta, Chakraborty, Ansari, Paudel, Chikoti, Chandran: "Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes." in: Journal of virology, Vol. 87, Issue 8, pp. 4417-31, (2013) (PubMed).

Ansari, Singh, Dutta, Veettil, Dutta, Chikoti, Lu, Everly, Chandran: "Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells." in: Journal of virology, Vol. 87, Issue 15, pp. 8606-23, (2013) (PubMed).

Target Details for PYCARD

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Alternative Name: ASC / TMS1 (PYCARD Products)

Synonyms: ASC antibody, CARD5 antibody, TMS antibody, TMS-1 antibody, TMS1 antibody, 9130417A21Rik antibody, Asc antibody, TNS1 antibody, masc antibody, asc1 antibody, zAsc antibody, zgc:109874 antibody, PYD and CARD domain containing antibody, PYCARD antibody, Pycard antibody, pycard antibody

Background: Synonyms: PYCARD, PYD and CARD domain containing, ASC, CARD5, MGC10332, TMS, TMS1, apoptosis-associated speck-like protein containing a CARD, caspase recruitment domain protein 5, target of methylation-induced silencing-1

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome