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tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (N-Term) antibody

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Antigen
Alternatives
Epitope
N-Term
(23), (12), (12), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(114), (39), (37), (6), (5), (5), (3), (2), (2), (2), (2), (1), (1)
Host
Rabbit
(99), (23)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (5), (5), (2), (2), (1), (1)
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
(102), (49), (36), (30), (24), (12), (9), (6), (5), (1), (1)
Pubmed 3 references available
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Quantity 100 μL
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Specificity A synthetic peptide corresponding to residues near N-terminus of human 14-3-3 beta/alpha was used as immunogen. Predicted to cross-react with sheep and bovine, based on sequence homology.
Alternative Name 14-3-3 B/a (YWHAB Antibody Abstract)
Background The 14-3-3 proteins are a family of proteins involved in the regulation of apoptosis, mitogenic signaling and cell-cycle checkpoints (1). The 14-3-3 proteins are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins (2,3). Through binding Bad, 14-3-3 prevents apoptosis by sequestering Bad to the cytosol (3)
Synonyms: YWHAB, 14-3-3 protein beta/alpha, N-terminally processed, Protein 1054
Molecular Weight 30 kDA
Gene ID 7529
UniProt P31946
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: = 1:1000, FACS: = 1:50, IHC: = 1:250
Comment

Background: The 14-3-3 proteins are a family of proteins involved in the regulation of apoptosis, mitogenic signaling and cell-cycle checkpoints (1). The 14-3-3 proteins are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins (2,3). Through binding Bad, 14-3-3 prevents apoptosis by sequestering Bad to the cytosol (3)

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment 14-3-3 b/a Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Fu, Subramanian, Masters: "14-3-3 proteins: structure, function, and regulation." in: Annual review of pharmacology and toxicology, Vol. 40, pp. 617-47, 2000 (PubMed).

Zha, Harada, Yang et al.: "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)" in: Cell, Vol. 87, Issue 4, pp. 619-28, 1997 (PubMed).

Muslin, Tanner, Allen et al.: "Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine." in: Cell, Vol. 84, Issue 6, pp. 889-97, 1996 (PubMed).

Catalog No. ABIN649226

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