tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) antibody

Details for Product No. ABIN649227
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Antigen
Synonyms
14-3-3, 14-3-3 epsilon, 14-3-3-e, 14-3-3-epsilon, 14-3-30epsilon, 14-3-3EPSILON, 14-3-3e, 14-3-3omicron, 1433epsilon, 143E_DROME, CG31196, CT24092, D14-3-3e, D14-3-3epsilon, Dmel\\CG31196, EK3-5, PAR- ... show more
14-3-3, 14-3-3 epsilon, 14-3-3-e, 14-3-3-epsilon, 14-3-30epsilon, 14-3-3EPSILON, 14-3-3e, 14-3-3omicron, 1433epsilon, 143E_DROME, CG31196, CT24092, D14-3-3e, D14-3-3epsilon, Dmel\\CG31196, EK3-5, PAR-5, PAR5, Par-5, SR3-9, Su(Raf)3B, anon-WO0172774.141, anon-WO02059370.52, d14-3-3epsilon, eps, l(3)j2B10, par-5, 14-3-3epsilon, kcip-1, mdcr, mds, LOC581376, Ywhae, ACYPI002517, YWHAE, 14-3-3E, KCIP-1, MDCR, MDS, AU019196, fe38c12, wu:fb48f06, wu:fe38c12, wu:fi22e10, ywhae, zgc:55377, zgc:77062 show less
Reactivity
Human, Rat (Rattus)
(79), (56), (48), (18), (17), (9), (4), (2), (2), (1), (1)
Host
Rabbit
(71), (19), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunofluorescence (IF)
(72), (33), (23), (20), (15), (11), (6), (6), (4), (2), (1)
Pubmed 4 references available
Quantity 100 μL
Options
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Catalog No. ABIN649227
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Specificity A synthetic peptide corresponding to residues in human 14-3-3E was used as an immunogen.
Alternative Name 14-3-3E
Background The 14-3-3 epsilon protein (14-3-3E) is one of seven isoforms in the 14-3-3 protein family, a family which consists of acidic 30 kDa proteins expressed at high levels in neurons of the central nervous system (1). It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3E binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (2). It also interacts with both, the insulin-like growth factor I receptor (IGFIR) and the insulin receptor substrate I (IRS-1), suggesting its role in the regulation of insulin sensitivity (3). 14-3-3E has also been implicated in the pathogenesis of small cell lung cancer (4).
Molecular Weight 30 kDA
Gene ID 93659, 94027, 1082
UniProt P62258
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:20000-100000
Comment

Background: The 14-3-3 epsilon protein (14-3-3E) is one of seven isoforms in the 14-3-3 protein family, a family which consists of acidic 30 kDa proteins expressed at high levels in neurons of the central nervous system (1). It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3E binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (2). It also interacts with both, the insulin-like growth factor I receptor (IGFIR) and the insulin receptor substrate I (IRS-1), suggesting its role in the regulation of insulin sensitivity (3). 14-3-3E has also been implicated in the pathogenesis of small cell lung cancer (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment 14-3-3E Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Craparo, Freund, Gustafson: "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner." in: The Journal of biological chemistry, Vol. 272, Issue 17, pp. 11663-9, 1997 (PubMed).

Satoh, Yamamura, Arima: "The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes." in: The American journal of pathology, Vol. 165, Issue 2, pp. 577-92, 2004 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

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