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Details for Product No. ABIN649230

Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) antibody

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Antigen
Synonyms ATQ, wu:fi34d12, wu:fi35e06, antiquitin, Atq1, D18Wsu181e, ATQ1, EPD, PDE, atq1, ALDH7A1
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 3 references available
Catalog no. ABIN649230
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues near the N-terminus of human Aldh7a1 was used as an immunogen.
Alternative Name Aldh7A1
Background Antiquitin (Aldh7a1) is an evolutionarily conserved protein believed to play a role in the regulation of cellular turgor. Based on sequence analysis, this protein is classified as a member of the aldehyde dehydrogenase superfamily (1). Analysis of the amount of mRNA in various rat and human tissues indicates that the largest amounts are found in rat kidney and liver and in cultured human hepatoma cells. Only minimal amounts were detected in human peripheral blood leukocytes, rat lung, or cultured human fibroblasts (2). The plant homolog of ATQ1 is thought to be involved in regulating turgor pressure, a function that also would be essential for cells of the mammalian cochlea. Northern blots of 13 human fetal tissues show antiquitin to be highly expressed in cochlea, ovary, eye, heart, and kidney (3).
Synonyms: ALDH7A1, ATQ1, Alpha-aminoadipic semialdehyde dehydrogenase, Aldehyde dehydrogenase family 7 member A1,Antiquitin-1
Molecular Weight 55 kDA
Gene ID 501
UniProt P49419
Research Area Neurology, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:500 FC: ~~ 1:30 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250
Comment

Background: Antiquitin (Aldh7a1) is an evolutionarily conserved protein believed to play a role in the regulation of cellular turgor. Based on sequence analysis, this protein is classified as a member of the aldehyde dehydrogenase superfamily (1). Analysis of the amount of mRNA in various rat and human tissues indicates that the largest amounts are found in rat kidney and liver and in cultured human hepatoma cells. Only minimal amounts were detected in human peripheral blood leukocytes, rat lung, or cultured human fibroblasts (2). The plant homolog of ATQ1 is thought to be involved in regulating turgor pressure, a function that also would be essential for cells of the mammalian cochlea. Northern blots of 13 human fetal tissues show antiquitin to be highly expressed in cochlea, ovary, eye, heart, and kidney (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Aldh7A1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lee, Kuhl, Gelbart et al.: "Homology between a human protein and a protein of the green garden pea." in: Genomics, Vol. 21, Issue 2, pp. 371-8, 1994 (PubMed).

Skvorak, Robertson, Yin et al.: "An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1)." in: Genomics, Vol. 46, Issue 2, pp. 191-9, 1998 (PubMed).

Tang, Cheng, Fong: "First purification of the antiquitin protein and demonstration of its enzymatic activity." in: FEBS letters, Vol. 516, Issue 1-3, pp. 183-6, 2002 (PubMed).

Alternatives for antigen "Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1)", type "Antibodies"
Hosts (25), (2)
Reactivities (16), (8), (6), (2), (1), (1)
Applications (26), (14), (9), (8), (8), (6), (4), (3), (2), (2), (1)
Conjugates (6)
Epitopes (2), (2), (2), (2), (1)
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