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Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) antibody

Details for Product No. ABIN649231
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Antigen
Synonyms TNFSF9, 4-1BB-L, 4-1BBL, AI848817, Cd137l, Ly63l, CD137L
Reactivity
Human
(62), (32)
Host
Rabbit
(47), (29), (17), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(14), (10), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(53), (52), (37), (10), (10), (7), (6), (6), (4), (4), (1)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN649231
450.00 $
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Specificity A synthetic peptide corresponding to residues near the N-terminus of human 4-1BBL was used as an immunogen.
Alternative Name 4-1BBL
Background 4-1BB was originally described as a cDNA expressed by activated murine T cells and subsequently demonstrated to encode a member of the tumor necrosis factor receptor family of integral membrane proteins. Recently, a murine ligand for 4-1BB (mu4-1BB-L) was cloned and demonstrated to be a member of an emerging family of ligands with structural homology to tumor necrosis factor. Both monoclonal antibody to hu4-1BB and cells transfected with hu4-1BB-L induced a strong proliferative response in mitogen co-stimulated primary T cells. In contrast, ligation of 4-1BB on T cell clones enhanced activation-induced cell death when triggered by engagement of the TCR/CD3 complex. (1). To reject tumors, T cells must overcome poor tumor immunogenicity and an adverse tumor microenvironment. It has been shown that primary human T cells expressing CD80 and 4-1BBL vigorously respond to tumor cells lacking costimulatory ligands and provoke potent rejection of large, systemic tumors in immunodeficient mice (2).
Synonyms: TNFSF9, Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand
Molecular Weight 26 kDA
Gene ID 8744
UniProt P41273
Research Area Cell Signaling, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000
Comment

Background: 4-1BB was originally described as a cDNA expressed by activated murine T cells and subsequently demonstrated to encode a member of the tumor necrosis factor receptor family of integral membrane proteins. Recently, a murine ligand for 4-1BB (mu4-1BB-L) was cloned and demonstrated to be a member of an emerging family of ligands with structural homology to tumor necrosis factor. Both monoclonal antibody to hu4-1BB and cells transfected with hu4-1BB-L induced a strong proliferative response in mitogen co-stimulated primary T cells. In contrast, ligation of 4-1BB on T cell clones enhanced activation-induced cell death when triggered by engagement of the TCR/CD3 complex. (1). To reject tumors, T cells must overcome poor tumor immunogenicity and an adverse tumor microenvironment. It has been shown that primary human T cells expressing CD80 and 4-1BBL vigorously respond to tumor cells lacking costimulatory ligands and provoke potent rejection of large, systemic tumors in immunodeficient mice (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment 4-1BBL Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Alderson, Smith, Tough et al.: "Molecular and biological characterization of human 4-1BB and its ligand." in: European journal of immunology, Vol. 24, Issue 9, pp. 2219-27, 1994 (PubMed).

Stephan, Ponomarev, Brentjens et al.: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007 (PubMed).

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