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Details for Product No. ABIN649241

Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM) antibody

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Antigen
Synonyms ACAD1, MCAD, MCADH, AU018656, acaDM
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 3 references available
Catalog no. ABIN649241
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in human ACADM was used as an immunogen.
Alternative Name ACADM
Background Medium-chain specific acyl-CoA dehydrogenase (ACADM) is a homotetramer enzyme of the mitochondrial flavoenzyme family that catalyzes the initial reaction in medium chain fatty acid beta-oxidation (1, 2). ACADM is specific for acyl chain lengths of 4 to 16 (3). It utilizes the electron transfer flavoprotein (ETF) as an electron acceptor that transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (3). Defects in the ACADM gene cause medium-chain acyl-CoA dehydrogenase deficiency (MCADD), a metabolic disorder characterized by fasting hypoglycemia (3). Mutation analysis can diagnose MCADD, which is currently screened in newborns, since its monogene may be modified by genetic variations (4).
Molecular Weight 43 kDA
Gene ID 10232
UniProt P11310
Research Area Signaling, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:10~100 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250
Comment

Background: Medium-chain specific acyl-CoA dehydrogenase (ACADM) is a homotetramer enzyme of the mitochondrial flavoenzyme family that catalyzes the initial reaction in medium chain fatty acid beta-oxidation (1, 2). ACADM is specific for acyl chain lengths of 4 to 16 (3). It utilizes the electron transfer flavoprotein (ETF) as an electron acceptor that transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (3). Defects in the ACADM gene cause medium-chain acyl-CoA dehydrogenase deficiency (MCADD), a metabolic disorder characterized by fasting hypoglycemia (3). Mutation analysis can diagnose MCADD, which is currently screened in newborns, since its monogene may be modified by genetic variations (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment ACADM Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Zhang, Kelly, Kim et al.: "Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase gene." in: Biochemistry, Vol. 31, Issue 1, pp. 81-9, 1992 (PubMed).

Gregersen, Andresen, Corydon et al.: "Mutation analysis in mitochondrial fatty acid oxidation defects: Exemplified by acyl-CoA dehydrogenase deficiencies, with special focus on genotype-phenotype relationship." in: Human mutation, Vol. 18, Issue 3, pp. 169-89, 2001 (PubMed).

"The Universal Protein Resource (UniProt) 2009." in: Nucleic acids research, Vol. 37, Issue Database issue, pp. D169-74, 2008 (PubMed).

Alternatives for antigen "Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain (ACADM)", type "Antibodies"
Hosts (47), (8), (4)
Reactivities (57), (29), (24), (16), (15), (13), (12), (3), (1)
Applications (49), (16), (16), (10), (8), (7), (4), (3), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (4), (2), (2), (1), (1), (1)
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