Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE) antibody

Details for Product No. ABIN649245
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Antigen
Synonyms dcp, ace1, dcp1, xace, cd143, ACE1, CD143, DCP, DCP1, ICH, MVCD3, Dcp1, StsRR92, AW208573, ACE
Reactivity
Human
(119), (42), (27), (20), (18), (17), (2), (1), (1)
Host
Rabbit
(78), (49), (5), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(14), (14), (13), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(68), (67), (51), (31), (20), (18), (11), (10), (9), (1), (1), (1)
Pubmed 5 references available
Quantity 100 μL
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Catalog No. ABIN649245
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Specificity A synthetic peptide corresponding to residues on the C-terminus of human ACE was used as an immunogen.
Alternative Name ACE
Background Angiotensin-converting enzyme (ACE) is a zinc-containing dipeptidyl carboxypeptidase anchored in the plasma membrane with a carboxy-terminal hydrophobic domain (1, 2). ACE has a critical role in cardiovascular function because it catalyses the conversion of angiotensin I to the physiologically active vasopressor octapeptide angiotensin II, which controls fluid-electrolyte balance and systemic blood pressure (3, 4). Inhibitors of ACE are a first line of therapy for hypertension, heart failure, myocardial infarction and diabetic nephropathy (4). ACE also plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well as the local regulation that exists in tissues such as the myocardium and skeletal muscle (5).
Synonyms: ACE, DCP, DCP1, Angiotensin-converting enzyme, soluble form, Dipeptidyl carboxypeptidase I,Kininase II
Molecular Weight 195 kDA
Gene ID 1636
UniProt P12821
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Metabolism
Application Notes IHC: = 1:100-250, WB: = 1:1000-10000
Comment

Background: Angiotensin-converting enzyme (ACE) is a zinc-containing dipeptidyl carboxypeptidase anchored in the plasma membrane with a carboxy-terminal hydrophobic domain (1, 2). ACE has a critical role in cardiovascular function because it catalyses the conversion of angiotensin I to the physiologically active vasopressor octapeptide angiotensin II, which controls fluid-electrolyte balance and systemic blood pressure (3, 4). Inhibitors of ACE are a first line of therapy for hypertension, heart failure, myocardial infarction and diabetic nephropathy (4). ACE also plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well as the local regulation that exists in tissues such as the myocardium and skeletal muscle (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment ACE Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Ehlers, Fox, Strydom et al.: "Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 20, pp. 7741-5, 1989 (PubMed).

Sugimura, Tian, Hoffmann et al.: "Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization." in: Biochemical and biophysical research communications, Vol. 247, Issue 2, pp. 466-72, 1998 (PubMed).

Rieder, Taylor, Clark et al.: "Sequence variation in the human angiotensin converting enzyme." in: Nature genetics, Vol. 22, Issue 1, pp. 59-62, 1999 (PubMed).

Natesh, Schwager, Sturrock et al.: "Crystal structure of the human angiotensin-converting enzyme-lisinopril complex." in: Nature, Vol. 421, Issue 6922, pp. 551-4, 2003 (PubMed).

Natesh, Schwager, Evans et al.: "Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme." in: Biochemistry, Vol. 43, Issue 27, pp. 8718-24, 2004 (PubMed).

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