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Acyl Thioesterase 1 antibody

Details for Product No. ABIN649253
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Antigen
Reactivity
Human, Rat (Rattus)
(1), (1)
Host
Rabbit
(1)
Clonality
Monoclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN649253
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in human Acyl protein thioesterase 1 was used as an immunogen.
Background Acyl-protein thioesterase 1 (APT1, Lysophospholipase 1) is a member of a family of critical enzymes, lysophospholipases, that act on biological membranes to regulate the multifunctional lysophospholipids (1). APT1 hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (2). The role of APT1 in regulating lysophospholipids is important because increased levels of lysophospholipids are detected in a variety of diseases, including atherosclerosis and hyperlipidemia (1). Regulated expression of acyl-protein thioesterase by PKC has been suggested to have important implications for signal transduction processes (3).
Synonyms: LYPLA1, APT1, LPL1, Acyl-protein thioesterase 1, Lysophospholipase 1,Lysophospholipase I
Molecular Weight 24/21 kDA
Gene ID 10434
UniProt O75608
Research Area Metabolism, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:10000-20000
Comment

Background: Acyl-protein thioesterase 1 (APT1, Lysophospholipase 1) is a member of a family of critical enzymes, lysophospholipases, that act on biological membranes to regulate the multifunctional lysophospholipids (1). APT1 hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (2). The role of APT1 in regulating lysophospholipids is important because increased levels of lysophospholipids are detected in a variety of diseases, including atherosclerosis and hyperlipidemia (1). Regulated expression of acyl-protein thioesterase by PKC has been suggested to have important implications for signal transduction processes (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Acyl thioesterase 1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Wang, Yang, Friedman et al.: "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization." in: Biochimica et biophysica acta, Vol. 1437, Issue 2, pp. 157-69, 1999 (PubMed).

Wang, Johnson, Jones et al.: "Subcellular localization and PKC-dependent regulation of the human lysophospholipase A/acyl-protein thioesterase in WISH cells." in: Biochimica et biophysica acta, Vol. 1484, Issue 2-3, pp. 207-14, 2000 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649253
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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