Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2) antibody

Antigen: Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2)

Synonyms: AG2, GOB-4, HAG-2, XAG-2, PDIA17, Agr2h, Gob-4, mAG-2, MGC112187, wu:fj29g05, zgc:112187, agr2, AGR2, MGC128276, hag3, hag-3, bcmp11, MGC89004

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Certificates: ISO 9001:2008

Catalog no.: ABIN649263

Additional Information

Alternative name: AGR2

Gene ID: 10551

UniProt: O95994

Description: Other names: AGR2, AG2, Anterior gradient protein 2 homolog, Secreted cement gland protein XAG-2 homolog,HPC8

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human AGR2 was used as an immunogen.

Molecular Weight: 17 kDA

Comments:

Background: The anterior gradient protein-2 (AGR2) is a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. It has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells. Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells (1). Specifically, AGR2 may serve as a useful molecular marker and/or potential therapeutic target for hormone-responsive breast tumours (2). AGR2 expression promotes tumor growth in esophageal adenocarcinoma cells as well. Expression was detected in proliferating and differentiated intestinal cells of secretory lineage, suggesting that AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas (3).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:500~1000 ICC: ~~ 1:100 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: AGR2 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Cell Signaling, Protein Modifications, Cancer, Cell Structure

Restrictions: For Research Use only

Publications

Product: Wang, Hao, Lowe: "The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation." in: Cancer research, Vol. 68, Issue 2, pp. 492-7, 2008 (PubMed).