Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2) antibody

Details for Product No. ABIN649263
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms AG2, GOB-4, HAG-2, XAG-2, PDIA17, Agr2h, Gob-4, mAG-2, wu:fj29g05, zgc:112187, agr2, hag3, hag-3, bcmp11, MGC89004
Reactivity
Human, Rat (Rattus)
(95), (40), (23), (16), (14), (13), (2), (1), (1), (1)
Host
Rabbit
(80), (22), (7), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(9), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(77), (63), (44), (27), (10), (9), (7), (6), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN649263
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in human AGR2 was used as an immunogen.
Alternative Name AGR2
Background The anterior gradient protein-2 (AGR2) is a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. It has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells. Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells (1). Specifically, AGR2 may serve as a useful molecular marker and/or potential therapeutic target for hormone-responsive breast tumours (2). AGR2 expression promotes tumor growth in esophageal adenocarcinoma cells as well. Expression was detected in proliferating and differentiated intestinal cells of secretory lineage, suggesting that AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas (3).
Synonyms: AGR2, AG2, Anterior gradient protein 2 homolog, Secreted cement gland protein XAG-2 homolog,HPC8
Molecular Weight 17 kDA
Gene ID 10551
UniProt O95994
Research Area Cell Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500-1000
Comment

Background: The anterior gradient protein-2 (AGR2) is a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. It has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells. Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells (1). Specifically, AGR2 may serve as a useful molecular marker and/or potential therapeutic target for hormone-responsive breast tumours (2). AGR2 expression promotes tumor growth in esophageal adenocarcinoma cells as well. Expression was detected in proliferating and differentiated intestinal cells of secretory lineage, suggesting that AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment AGR2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Wang, Hao, Lowe: "The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation." in: Cancer research, Vol. 68, Issue 2, pp. 492-7, 2008 (PubMed).

Hosts (80), (22), (7), (1)
Reactivities (95), (40), (23), (16), (14), (13), (2), (1), (1), (1)
Applications (77), (63), (44), (27), (10), (9), (7), (6), (1), (1)
Conjugates (9), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (13), (9), (9), (8), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top