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Details for Product No. ABIN649273

Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) antibody

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Antigen
Synonyms ALDH1, GGADHR, ALDDH, ALDC, ALDH-E1, ALDH11, PUMB1, RALDH1, Ahd2, Aldh1, Aldh2, E1, Ahd-2, Raldh1, Aldh1a2, AL1A1, aldc, aldh-e1, aldh1, aldh11, pumb1, raldh1, ALDH1A1
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN649273
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues near the C-terminus of human Aldh1a1 was used as an immunogen.
Alternative Name Aldh1A1
Background Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3).
Synonyms: ADH1B, ADH2, Alcohol dehydrogenase 1B, Alcohol dehydrogenase subunit beta
Molecular Weight 55 kDA
Gene ID 125
UniProt P00325
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:2000 IP: ~~ 1:30 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250
Comment

Background: Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Aldh1A1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Yoshida, Ikawa, Hsu et al.: "Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases." in: Alcohol (Fayetteville, N.Y.), Vol. 2, Issue 1, pp. 103-6, 1985 (PubMed).

Alternatives for antigen "Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1)", type "Antibodies"
Hosts (64), (17), (15)
Reactivities (92), (51), (49), (38), (24), (16)
Applications (66), (38), (30), (30), (19), (12), (7), (6), (3), (3)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (8), (5), (4), (2), (2), (2), (2), (1), (1), (1)
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