Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) antibody

Antigen: Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1)

Synonyms: ALDH1A1, ALDH1, MGC128391, AL1A1, aldc, aldh1, pumb1, aldh11, raldh1, aldh-e1, MGC107771, GGADHR, DKFZp469B0514, ALDDH, ALDC, PUMB1, ALDH11, RALDH1, ALDH-E1, MGC2318, Ahd2, Aldh1, Aldh2, E1, Ahd-2, Raldh1, Aldh1a2

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Certificates: ISO 9001:2008

Catalog no.: ABIN649274

Additional Information

Alternative name: Aldh1A1

Gene ID: 125

UniProt: P00325

Description: Other names: ADH1B, ADH2, Alcohol dehydrogenase 1B, Alcohol dehydrogenase subunit beta

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human ALdh1a1 was used as an immunogen.

Molecular Weight: 55 kDA

Comments:

Background: Acetaldehyde dehydrogenase (ALDH) is the next enzyme after alcohol dehydrogenase in the major pathways of alcohol metabolism. Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3).

Synonyms: ALDH1A1, ALDH1, MGC128391, AL1A1, aldc, aldh1, pumb1, aldh11, raldh1, aldh-e1, MGC107771, GGADHR, DKFZp469B0514, ALDDH, ALDC, PUMB1, ALDH11, RALDH1, ALDH-E1, MGC2318, Ahd2, Aldh1, Aldh2, E1, Ahd-2, Raldh1, Aldh1a2

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: Aldh1A1 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Yoshida, Ikawa, Hsu et al.: "Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases." in: Alcohol (Fayetteville, N.Y.), Vol. 2, Issue 1, pp. 103-6, 1985 (PubMed).