Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) antibody

Details for Product No. ABIN649274
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Antigen
Synonyms AL1A1, aldc, aldh-e1, aldh1, aldh11, pumb1, raldh1, ALDH1A1, ALDC, ALDH-E1, ALDH1, ALDH11, PUMB1, RALDH1, Ahd2, Aldh1, Aldh2, GGADHR, ALDDH, Ahd-2, Aldh1a2, E1, Raldh1
Reactivity
Human
(133), (52), (52), (38), (24), (16), (1)
Host
Rabbit
(91), (28), (15)
Clonality
Monoclonal
Conjugate
Un-conjugated
(9), (7), (7), (6), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(93), (61), (35), (31), (30), (25), (14), (14), (8), (3)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN649274
450.00 $
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Specificity A synthetic peptide corresponding to residues in human ALdh1a1 was used as an immunogen.
Alternative Name Aldh1A1
Background Acetaldehyde dehydrogenase (ALDH) is the next enzyme after alcohol dehydrogenase in the major pathways of alcohol metabolism. Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3).
Synonyms: ADH1B, ADH2, Alcohol dehydrogenase 1B, Alcohol dehydrogenase subunit beta
Molecular Weight 55 kDA
Gene ID 125
UniProt P00325
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000 ,IHC: = 1:100-250
Comment

Background: Acetaldehyde dehydrogenase (ALDH) is the next enzyme after alcohol dehydrogenase in the major pathways of alcohol metabolism. Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Aldh1A1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Yoshida, Ikawa, Hsu et al.: "Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases." in: Alcohol (Fayetteville, N.Y.), Vol. 2, Issue 1, pp. 103-6, 1985 (PubMed).

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