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Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) antibody
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunocytochemistry (ICC)
|3 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: SNCA, NACP, PARK1, Alpha-synuclein, Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues on the N-terminus of human Alpha-synuclein was used as an immunogen.|
|Molecular Weight||18 kDA|
Background: Alpha-Synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson',s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson',s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3).
|Application Notes||The suggested dilution is: WB: ~~ 1:1000~5000 ICC: ~~ 1:50~100|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Alpha-Synuclein Antibody can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure, Neurology|
|Restrictions||For Research Use only|
Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).
Shimura, Schlossmacher, Hattori et al.: "Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease." in: Science (New York, N.Y.), Vol. 293, Issue 5528, pp. 263-9, 2001 (PubMed).
Fujiwara, Hasegawa, Dohmae et al.: "alpha-Synuclein is phosphorylated in synucleinopathy lesions." in: Nature cell biology, Vol. 4, Issue 2, pp. 160-4, 2002 (PubMed).