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Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) antibody

Antigen

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunocytochemistry (ICC)
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN649287
Quantity 100ul
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name Alpha-Synuclein
Gene ID 6622
UniProt P37840
Description Other names: SNCA, NACP, PARK1, Alpha-synuclein, Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues on the N-terminus of human Alpha-synuclein was used as an immunogen.
Molecular Weight 18 kDA
Comments

Background: Alpha-Synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson',s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson',s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:1000~5000 ICC: ~~ 1:50~100
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Alpha-Synuclein Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure, Neurology
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).

Shimura, Schlossmacher, Hattori et al.: "Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease." in: Science (New York, N.Y.), Vol. 293, Issue 5528, pp. 263-9, 2001 (PubMed).

Fujiwara, Hasegawa, Dohmae et al.: "alpha-Synuclein is phosphorylated in synucleinopathy lesions." in: Nature cell biology, Vol. 4, Issue 2, pp. 160-4, 2002 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)", type "Antibodies"
Hosts Rabbit (225), Mouse (67), Goat (15), Sheep (4), Rat (1)
Reactivities Human (300), Rat (Rattus) (173), Mouse (Murine) (164), Cow (Bovine) (128), Pig (Porcine) (128), Dog (Canine) (111), Horse (Equine) (107), Sheep (Ovine) (107), Chicken (35), Guinea Pig (35), Rabbit (17), Mammalian (1), Monkey (1)
Applications Western Blotting (WB) (159), Immunofluorescence (IF) (148), ELISA (100), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (62), Immunohistochemistry (IHC) (34), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (23), Immunoprecipitation (IP) (19), Immunocytochemistry (ICC) (16), Immunoelectron Microscopy (IEM) (8), Immunohistochemistry (Fixed) (IHC (fx)) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Enzyme Immunoassay (EIA) (2), Radioimmunoassay (RIA) (2)
Conjugates Biotin (11), FITC (9), HRP (9), Cy3 (8), Cy5 (8), Cy5.5 (8), Cy7 (8), Gold (8), PE (8), Alexa Fluor 350 (7), Alexa Fluor 488 (7), Alexa Fluor 555 (7), Alexa Fluor 647 (7), PE,Cy3 (7), PE,Cy5 (7), PE,Cy7 (7), PE,Cy5.5 (6), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
Epitopes C-Term (38), pSer129 (33), pTyr133 (25), pTyr136 (25), pTyr125 (24), N-Term (18), nTyr39 (17), AA 61-95 (7), AA 1-140 (5), Internal Region (4), AA 108-120 (3), AA 116-131 (3), AA 111-131 (2), Tyr133 (2), pSer87 (2), AA 116-113 (1), AA 129-140 (1)