Synuclein, alpha (SNCA) antibody

Details for Product No. ABIN649287
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Antigen
Reactivity
Human, Rat (Rattus)
(537), (228), (212), (9), (9), (7), (2), (2), (1), (1), (1)
Host
Rabbit
(411), (115), (31), (10), (2), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(20), (16), (13), (7), (7), (7), (7), (7), (7), (7), (7), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(398), (201), (123), (101), (86), (70), (23), (21), (20), (19), (11), (6), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 100 μL
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Specificity A synthetic peptide corresponding to residues on the N-terminus of human Alpha-synuclein was used as an immunogen.
Alternative Name alpha-Synuclein (SNCA Antibody Abstract)
Background Alpha-Synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson',s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson',s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3).
Synonyms: SNCA, NACP, PARK1, Alpha-synuclein, Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor
Molecular Weight 18 kDA
Gene ID 6622
UniProt P37840
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure, Neurology
Application Notes The suggested dilution is: WB: = 1:1000-5000
Comment

Background: Alpha-Synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson',s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson',s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Alpha-Synuclein Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Fujiwara, Hasegawa, Dohmae et al.: "alpha-Synuclein is phosphorylated in synucleinopathy lesions." in: Nature cell biology, Vol. 4, Issue 2, pp. 160-4, 2002 (PubMed).

Shimura, Schlossmacher, Hattori et al.: "Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease." in: Science (New York, N.Y.), Vol. 293, Issue 5528, pp. 263-9, 2001 (PubMed).

Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).

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Catalog No. ABIN649287
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