alpha Tubulin (TUBA1) (pTyr272) antibody

Details for Product No. ABIN649290
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms K-ALPHA-1, TUBA2, mec-12, tuba4
Epitope
pTyr272
(13), (8), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(82), (35), (33), (23), (17), (13), (7), (6), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(71), (27), (12), (8), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(104), (36), (35), (30), (29), (25), (21), (10), (6), (6), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649290
507.14 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A phospho synthetic peptide corresponding to residues surrounding tyrosine 272 of human alpha-tubulin was used as an immunogen. This antibody detects alpha-tubulin phosphorylated at tyrosine 272.
Alternative Name Alpha-Tubulin
Background Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. An essential component of microtubules, alpha-tubulin is also a multigene family in many species (1). Familial amyloidosis, British type, is an autosomal dominant disease characterized by progressive dementia, spastic paralysis and ataxia. The identity of the accumulating amyloid is not known, thus preventing the definitive classification of the disease. Findings suggest that the C-terminal fragments of both alpha- and beta-tubulin are closely associated to the amyloid deposits of familial amyloidosis, British type (2).
Synonyms: TUBA1B, Tubulin alpha-1B chain, Tubulin alpha-ubiquitous chain,Alpha-tubulin ubiquitous,Tubulin K-alpha-1
Molecular Weight 52 kDA
Gene ID 10376
UniProt P68363
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:2500-5000
Comment

Background: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. An essential component of microtubules, alpha-tubulin is also a multigene family in many species (1). Familial amyloidosis, British type, is an autosomal dominant disease characterized by progressive dementia, spastic paralysis and ataxia. The identity of the accumulating amyloid is not known, thus preventing the definitive classification of the disease. Findings suggest that the C-terminal fragments of both alpha- and beta-tubulin are closely associated to the amyloid deposits of familial amyloidosis, British type (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Alpha-Tubulin Antibody Phospho (pY272) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Cowan, Dobner, Fuchs et al.: "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions." in: Molecular and cellular biology, Vol. 3, Issue 10, pp. 1738-45, 1984 (PubMed).

Validation Images
Did you look for something else?
back to top