Amyloid beta A4 (Variant 40) antibody

Antigen: Amyloid beta A4

Binding Site: Variant 40

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN649301

Additional Information

Gene ID: 351

UniProt: P05067

Description: Other names: APP, A4, AD1, C31, Gamma-CTF(50),Amyloid intracellular domain 50

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human Beta-amyloid protein 40 was used as immunogen. This antibody specifically recognizes Amyloid Beta Protein (Aβ,4) variant Aβ,-40.

Molecular Weight: 4 kDA

Comments:

Background: Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Aβ,4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4 kDa Aβ,4 protein. Two variants of Aβ,4 can be detected, Aβ,-40 short-tailed and Aβ,-42 long-tailed (3-4).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:500 (5ng)

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: Amyloid beta A4 Antibody Variant 40 can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Neurology

Restrictions: For Research Use only

Publications

Product: Glenner, Wong: "Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein." in: Biochemical and biophysical research communications, Vol. 120, Issue 3, pp. 885-90, 1984 (PubMed).

Vigo-Pelfrey, Lee, Keim et al.: "Characterization of beta-amyloid peptide from human cerebrospinal fluid." in: Journal of neurochemistry, Vol. 61, Issue 5, pp. 1965-8, 1993 (PubMed).