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Details for Product No. ABIN649301

Amyloid beta A4 (Variant 40) antibody

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Antigen
Epitope
»Alternatives Variant 40
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN649301
Quantity 100 µL
Price
392.86 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in human Beta-amyloid protein 40 was used as immunogen. This antibody specifically recognizes Amyloid Beta Protein (Aβ,4) variant Aβ,-40.
Background Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (ABeta4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4 kDa ABeta4 protein. Two variants of ABeta4 can be detected, ABeta-40 short-tailed and ABeta-42 long-tailed (3-4).
Synonyms: APP, A4, AD1, C31, Gamma-CTF(50),Amyloid intracellular domain 50
Molecular Weight 4 kDA
Gene ID 351
UniProt P05067
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Neurology
Application Notes The suggested dilution is: WB: ~~ 1:500 (5ng)
Comment

Background: Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Aβ,4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4 kDa Aβ,4 protein. Two variants of Aβ,4 can be detected, Aβ,-40 short-tailed and Aβ,-42 long-tailed (3-4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Amyloid beta A4 Antibody Variant 40 can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Glenner, Wong: "Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein." in: Biochemical and biophysical research communications, Vol. 120, Issue 3, pp. 885-90, 1984 (PubMed).

Vigo-Pelfrey, Lee, Keim et al.: "Characterization of beta-amyloid peptide from human cerebrospinal fluid." in: Journal of neurochemistry, Vol. 61, Issue 5, pp. 1965-8, 1993 (PubMed).

Alternatives for antigen "Amyloid beta A4", type "Antibodies"
Hosts (10)
Reactivities (10), (10), (10)
Applications (10), (10), (10), (8), (2)
Epitopes (5), (5)
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