Amyloid-beta A4 (APP) antibody

Details for Product No. ABIN649302
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Antigen
Reactivity
Human, Rat (Rattus)
Host
Rabbit
Clonality
Monoclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN649302
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Specificity A synthetic peptide corresponding to residues in the NPXY motif of human Amyloid Beta A4 precusor (APP) was used as immunogen. This antibody specifically recognizes APP and its isoforms. It will not recognize either of the two Amyloid Beta Protein ( A?4 ) variants, A?1 -40 or A?1 -42.
Background Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (A?4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4 kDa A?4 protein. Two variants of A?4 can be detected, A?1-40 short-tailed and A?1-42 long-tailed (3-4).
Synonyms: APP, A4, AD1, C31, Gamma-CTF(50),Amyloid intracellular domain 50
Molecular Weight 95 kDA
Gene ID 351
UniProt P05067
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Application Notes The suggested dilution is: WB: = 1:1000-10000 , IHC: = 1:250-500
Comment

Background: Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (A?4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4 kDa A?4 protein. Two variants of A?4 can be detected, A?1-40 short-tailed and A?1-42 long-tailed (3-4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Amyloid-Beta A4 Antibody (APP) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Masters, Simms, Weinman et al.: "Amyloid plaque core protein in Alzheimer disease and Down syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 12, pp. 4245-9, 1985 (PubMed).

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