Transcription Factor AP-2 gamma (Activating Enhancer Binding Protein 2 Gamma) (TFAP2C) antibody

Details for Product No. ABIN649306
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Antigen
Reactivity
Human
(73), (32), (28), (9), (6), (6), (3), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(38), (21), (18)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(44), (36), (25), (13), (10), (4), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 100 μL
Options
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Specificity A synthetic peptide corresponding to residues in human AP2 gamma was used as an immunogen.
Alternative Name AP2 gamma (TFAP2C Antibody Abstract)
Background Transcription factor gene AP2-C (AP-2 gamma) belongs to a family of four closely related genes. The AP-2 transcription factor has been shown to play an important role in the development of tissues of ectodermal origin and has also been implicated in mammary oncogenesis (2). A physical and functional association between AP-2gamma transcription factor and the Wwox protein has been demonstrated. results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm (2). P-2 gamma had been implicated in multiple functions during proliferation and differentiation based on its expression pattern in trophoblast, neural crest, and ectoderm cells in murine embryos. AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells (3).
Synonyms: TFAP2C, Transcription factor AP-2 gamma, Activating enhancer-binding protein 2 gamma,Transcription factor ERF-1
Molecular Weight 49 kDA
Gene ID 7022
UniProt Q92754
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes IHC: = 1:250-500, WB: = 1:500-1000
Comment

Background: Transcription factor gene AP2-C (AP-2 gamma) belongs to a family of four closely related genes. The AP-2 transcription factor has been shown to play an important role in the development of tissues of ectodermal origin and has also been implicated in mammary oncogenesis (2). A physical and functional association between AP-2gamma transcription factor and the Wwox protein has been demonstrated. results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm (2). P-2 gamma had been implicated in multiple functions during proliferation and differentiation based on its expression pattern in trophoblast, neural crest, and ectoderm cells in murine embryos. AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment AP2 gamma Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Aqeilan, Palamarchuk, Weigel et al.: "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor." in: Cancer research, Vol. 64, Issue 22, pp. 8256-61, 2004 (PubMed).

Werling, Schorle: "Transcription factor gene AP-2 gamma essential for early murine development." in: Molecular and cellular biology, Vol. 22, Issue 9, pp. 3149-56, 2002 (PubMed).

Williamson, Bosher, Skinner et al.: "Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors." in: Genomics, Vol. 35, Issue 1, pp. 262-4, 1996 (PubMed).

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Catalog No. ABIN649306
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