Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) antibody

Details for Product No. ABIN649308
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms AP2S1, ap17, claps2, ap17-delta, DDBDRAFT_0188542, DDBDRAFT_0234236, DDB_0188542, DDB_0234236, MGC85224, AP17, AP17-DELTA, CLAPS2, HHC3, AI043088, Ap17
Reactivity
Human, Rat (Rattus)
(26)
Host
Rabbit
(22), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (4), (3), (1), (1), (1)
Application
Western Blotting (WB)
(26), (20), (9), (2), (2), (1)
Pubmed 2 references available
Quantity 100 μL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649308
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in human AP2S1 was used as an immunogen.
Alternative Name AP2S1
Background Adaptor-related protein complex 2 sigma-1 subunit (AP2S1, AP17) is the component of the adaptor complexes which links clathrin to receptors in coated vesicles. It is the smallest polypeptide chain component of AP-2, a heterotetramer composed of two large adaptins (alpha-type subunit, AP2 alpha, and beta-type subunit, AP2 beta), a medium adaptin (mu-type subunit, AP2 mu1) and a small adaptin (sigma-type subunit, AP2S1). AP-2 is one of two major clathrin-associated protein complexes that interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (1, 2).
Synonyms: AP2S1, AP17, CLAPS2, AP-2 complex subunit sigma, Adapter-related protein complex 2 sigma subunit,Adaptor protein complex AP-2 subunit sigma,Sigma2-adaptin,Plasma membrane adaptor AP-2 17 kDa protein,HA2 17 kDa subunit,Clathrin assembly protein 2 small cha
Molecular Weight 17 kDA
Gene ID 1175
UniProt P53680
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-5000
Comment

Background: Adaptor-related protein complex 2 sigma-1 subunit (AP2S1, AP17) is the component of the adaptor complexes which links clathrin to receptors in coated vesicles. It is the smallest polypeptide chain component of AP-2, a heterotetramer composed of two large adaptins (alpha-type subunit, AP2 alpha, and beta-type subunit, AP2 beta), a medium adaptin (mu-type subunit, AP2 mu1) and a small adaptin (sigma-type subunit, AP2S1). AP-2 is one of two major clathrin-associated protein complexes that interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (1, 2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment AP2S1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kirchhausen, Davis, Frucht et al.: "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast." in: The Journal of biological chemistry, Vol. 266, Issue 17, pp. 11153-7, 1991 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Validation Images
Did you look for something else?
back to top