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Details for Product No. ABIN649308

Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) antibody

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Antigen
Synonyms AP17, AP17-DELTA, CLAPS2, HHC3, Ap17, AI043088, AP2S1, ap17, claps2, ap17-delta, DDBDRAFT_0188542, DDBDRAFT_0234236, DDB_0188542, DDB_0234236, MGC85224
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Application
»Alternatives Western Blotting (WB), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN649308
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Specificity A synthetic peptide corresponding to residues in human AP2S1 was used as an immunogen.
Alternative Name AP2S1
Background Adaptor-related protein complex 2 sigma-1 subunit (AP2S1, AP17) is the component of the adaptor complexes which links clathrin to receptors in coated vesicles. It is the smallest polypeptide chain component of AP-2, a heterotetramer composed of two large adaptins (alpha-type subunit, AP2 alpha, and beta-type subunit, AP2 beta), a medium adaptin (mu-type subunit, AP2 mu1) and a small adaptin (sigma-type subunit, AP2S1). AP-2 is one of two major clathrin-associated protein complexes that interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (1, 2).
Synonyms: AP2S1, AP17, CLAPS2, AP-2 complex subunit sigma, Adapter-related protein complex 2 sigma subunit,Adaptor protein complex AP-2 subunit sigma,Sigma2-adaptin,Plasma membrane adaptor AP-2 17 kDa protein,HA2 17 kDa subunit,Clathrin assembly protein 2 small cha
Molecular Weight 17 kDA
Gene ID 1175
UniProt P53680
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~5000 IP: ~~ 1:20 FC: ~~ 1:200 ICC: ~~ 1:100~250
Comment

Background: Adaptor-related protein complex 2 sigma-1 subunit (AP2S1, AP17) is the component of the adaptor complexes which links clathrin to receptors in coated vesicles. It is the smallest polypeptide chain component of AP-2, a heterotetramer composed of two large adaptins (alpha-type subunit, AP2 alpha, and beta-type subunit, AP2 beta), a medium adaptin (mu-type subunit, AP2 mu1) and a small adaptin (sigma-type subunit, AP2S1). AP-2 is one of two major clathrin-associated protein complexes that interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (1, 2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment AP2S1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kirchhausen, Davis, Frucht et al.: "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast." in: The Journal of biological chemistry, Vol. 266, Issue 17, pp. 11153-7, 1991 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Alternatives for antigen "Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1)", type "Antibodies"
Hosts (4), (4)
Reactivities (8)
Applications (8), (4), (1), (1), (1), (1)
Epitopes (3), (2), (1), (1), (1)
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