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APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) antibody

Details for Product No. ABIN649311
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Antigen
Synonyms APE, Apex, REF-1, APEN, BAP1, APX, APE1, APEX, HAP1, REF1, apex1a, hm:zehn1532, wu:fc13d11, zgc:66204, apex1, MGC76280, MGC79645, MGC78928
Reactivity
Human, Rat (Rattus)
(112), (42), (39), (19), (18), (17), (12), (1), (1), (1)
Host
Rabbit
(83), (29), (10)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(106), (38), (32), (22), (15), (13), (10), (6), (6), (5), (2), (2), (2), (1)
Pubmed 4 references available
Quantity 100 µL
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN649311
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues near the N-terminus in human Ape 1 was used as an immunogen.
Alternative Name Ape-1
Background Apurinic endonuclease (Ape 1) functions as a major DNA repair enzyme that is essential for embryogenesis and cell viability (1). It is involved in the base excision repair (BER) pathway and acts as a reduction-oxidation signaling factor to maintain transcription factors in an active reduced state (2). Ape 1 plays a critical role as a transcriptional coactivator for different transcription factors (i.e. AP-1, NF-kappaB, p53) in controlling different cellular processes such as apoptosis, proliferation, and differentiation (3). Elevated levels of Ape 1 have been found in cancers such as ovarian, cervical, and prostate (4).
Molecular Weight 36 kDA
Gene ID 5599
UniProt P27695
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure
Application Notes IHC: = 1 : 100-250, WB: = 1:10000-50000
Comment

Background: Apurinic endonuclease (Ape 1) functions as a major DNA repair enzyme that is essential for embryogenesis and cell viability (1). It is involved in the base excision repair (BER) pathway and acts as a reduction-oxidation signaling factor to maintain transcription factors in an active reduced state (2). Ape 1 plays a critical role as a transcriptional coactivator for different transcription factors (i.e. AP-1, NF-kappaB, p53) in controlling different cellular processes such as apoptosis, proliferation, and differentiation (3). Elevated levels of Ape 1 have been found in cancers such as ovarian, cervical, and prostate (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Ape-1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Evans, Limp-Foster, Kelley: "Going APE over ref-1." in: Mutation research, Vol. 461, Issue 2, pp. 83-108, 2001 (PubMed).

Tell, Damante, Caldwell et al.: "The intracellular localization of APE1/Ref-1: more than a passive phenomenon?" in: Antioxidants & redox signaling, Vol. 7, Issue 3-4, pp. 367-84, 2005 (PubMed).

Fishel, He, Reed et al.: "Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth." in: DNA repair, Vol. 7, Issue 2, pp. 177-86, 2008 (PubMed).

Manvilla, Varney, Drohat: "Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1." in: Biomolecular NMR assignments, Vol. 4, Issue 1, pp. 5-8, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN649311
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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