anti-Aquaporin 5 antibody (AQP5)

Details for Product anti-AQP5 Antibody No. ABIN649321
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Antigen
Reactivity
Human
(53), (28), (24), (1), (1)
Host
Rabbit
(69)
Clonality
Monoclonal
Conjugate
This Aquaporin 5 antibody is un-conjugated
(4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(51), (22), (15), (10), (5), (3), (3), (3), (2), (1)
Pubmed 4 references available
Quantity 100 μL
Options
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Specificity A synthetic peptide corresponding to residues in human Aquaporin 5 was used as an immunogen.
Alternative Name Aquaporin-5 (AQP5 Antibody Abstract)
Background Aquaporin 5 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions (1). It is expressed in epithelia of lung, cornea, and various secretory glands, sites where extracellular osmolality is known to fluctuate (2). Expression of Aquaporin 5 may have pathophysiological implications attributed to a dysfunctional water regulation by Aquaporin 5such as endolymphatic hydrops (i.e. in Meniere's disease) or sensorineural hearing loss (i.e. in Sj�gren's syndrome) (3). Up-regulation of Aquaporin 5 may be involved in differentiation of human gastric cancer cells (4).
Molecular Weight 27 kDA
Gene ID 9588
UniProt P55064
Research Area Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-10000
Comment

Background: Aquaporin 5 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions (1). It is expressed in epithelia of lung, cornea, and various secretory glands, sites where extracellular osmolality is known to fluctuate (2). Expression of Aquaporin 5 may have pathophysiological implications attributed to a dysfunctional water regulation by Aquaporin 5such as endolymphatic hydrops (i.e. in Meniere's disease) or sensorineural hearing loss (i.e. in Sj�gren's syndrome) (3). Up-regulation of Aquaporin 5 may be involved in differentiation of human gastric cancer cells (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Aquaporin-5 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Hirt, Penkova, Eckhard et al.: "The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph-endolymph barrier." in: Neuroscience, Vol. 168, Issue 4, pp. 957-70, 2010 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Sidhaye, Güler, Schweitzer et al.: "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 12, pp. 4747-52, 2006 (PubMed).

Da Silva, Silberstein, Beaulieu et al.: "Postnatal expression of aquaporins in epithelial cells of the rat epididymis." in: Biology of reproduction, Vol. 74, Issue 2, pp. 427-38, 2006 (PubMed).

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Catalog No. ABIN649321
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