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Agouti Signaling Protein (ASIP) antibody

Details for Product No. ABIN649323
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Antigen
Synonyms ASIP, AGSW, AGTI, AGTIL, ASP, SHEP9, A, As, AA960621, AI256638, D8Ertd580e, PAR-3, Par3, Pard3a
Reactivity
Human
(3), (2)
Host
Rabbit
(5)
Clonality
Monoclonal
Application
Western Blotting (WB)
(3), (3), (2), (1)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN649323
450.00 $
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Specificity A synthetic peptide corresponding to residues near the C-terminus of human ASIP was used as immunogen. This antibody is predicted to detect isoforms 2-7 based on sequence analysis.
Alternative Name ASIP
Background The agouti signaling protein (ASIP) is an adaptor protein involved in asymmetrical cell division and cell polarization processes. ASIP seems to play a central role in the formation of epithelial tight junctions. ASIP may affect the quality of hair pigmentation, and act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone (2-3). ASIP may also play a role in neuroendocrine aspects of melanocortin action, and have a functional role in regulating lipid metabolism in adipocytes (4-5).
Synonyms: PARD3, PAR3, PAR3A, Partitioning defective 3 homolog, CTCL tumor antigen se2-5,PAR3-alpha
Molecular Weight 150 kDA
Gene ID 56288
UniProt Q8TEW0
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:500
Comment

Background: The agouti signaling protein (ASIP) is an adaptor protein involved in asymmetrical cell division and cell polarization processes. ASIP seems to play a central role in the formation of epithelial tight junctions. ASIP may affect the quality of hair pigmentation, and act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone (2-3). ASIP may also play a role in neuroendocrine aspects of melanocortin action, and have a functional role in regulating lipid metabolism in adipocytes (4-5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment ASIP Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kwon, Bultman, Löffler et al.: "Molecular structure and chromosomal mapping of the human homolog of the agouti gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 21, pp. 9760-4, 1994 (PubMed).

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